Sahu Monashis, Bhatia Vijayalakshmi, Aggarwal Anjoo, Rawat Vinita, Saxena Priya, Pandey Amita, Das Vinita
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Clin Endocrinol (Oxf). 2009 May;70(5):680-4. doi: 10.1111/j.1365-2265.2008.03360.x. Epub 2008 Jul 31.
Vitamin D deficiency is common in urban Indians despite living in the tropics and its public health consequences are enormous. However, 70% of India is rural, and data from rural subjects, who are expected to have good sun exposure, are scant.
To determine the population prevalence of vitamin D deficiency in rural pregnant women and adolescent girls, compare serum 25-hydroxyvitamin D (25OHD) status in adolescent boys from the same families, and determine seasonal differences in serum 25OHD.
A cross-sectional study conducted over 18 months.
A random selection of 121 adolescent girls from a survey of a population of 8270 in a rural low socioeconomic community; 139 pregnant women in the second trimester; and a subset of 28 adolescent girls compared with 34 brothers.
Serum 25OHD, serum alkaline phosphatase (AP), sun exposure, and dietary calcium intake.
The age-adjusted community prevalence of vitamin D deficiency (25OHD < 50 nmol/l) in adolescent girls was 88.6%. Seventy-four per cent of pregnant women had vitamin D deficiency. Mean +/- SD 25OHD in girls and women in summer was 55.5 +/- 19.8 nmol/l compared to 27.3 +/- 12.3 nmol/l in winter (P < 0.001). Winter serum 25OHD in boys (67.5 +/- 29.0 nmol/l) was higher than that in their sisters (31.3 +/- 13.5 nmol/l, P < 0.001).
We report a high prevalence of vitamin D deficiency among pregnant women and adolescent girls from a rural Indian community. Boys are relatively protected. Seasonal variation in serum 25OHD is significant at latitude 26 degrees N.
尽管生活在热带地区，但城市印度人中维生素D缺乏症很常见，其对公共卫生的影响巨大。然而，印度70%的人口居住在农村，而来自预期有充足阳光照射的农村人群的数据却很少。
确定农村孕妇和青春期女孩中维生素D缺乏症的人群患病率，比较来自同一家庭的青春期男孩的血清25-羟维生素D（25OHD）水平，并确定血清25OHD的季节差异。
一项为期18个月的横断面研究。
从一个农村低社会经济社区的8270人的调查中随机选取121名青春期女孩；139名孕中期孕妇；以及28名青春期女孩与34名兄弟组成的一个子集。
血清25OHD、血清碱性磷酸酶（AP）、阳光照射和膳食钙摄入量。
青春期女孩中经年龄调整的维生素D缺乏症（25OHD < 50 nmol/l）社区患病率为88.6%。74%的孕妇有维生素D缺乏症。女孩和女性夏季的平均±标准差25OHD为55.5±19.8 nmol/l，而冬季为27.3±12.3 nmol/l（P < 0.001）。男孩冬季的血清25OHD（67.5±29.0 nmol/l）高于其姐妹（31.3±13.5 nmol/l，P < 0.001）。
我们报告了印度一个农村社区孕妇和青春期女孩中维生素D缺乏症的高患病率。男孩相对受保护。在北纬26度，血清25OHD存在显著的季节变化。
