Tobin D J, Fenton D A, Kendall M D
Unit of Cell Biology, U.M.D.S., London, England.
Am J Dermatopathol. 1991 Jun;13(3):248-56. doi: 10.1097/00000372-199106000-00006.
The morphology and prevalence of different forms of cell degeneration in hair follicles in acute alopecia areata were investigated. In addition to apoptosis and necrosis, a third morphological pattern of cell degeneration, dark-cell transformation, was evident. Fifteen patients with untreated acute alopecia areata and three normal adults without hair loss were studied. Electron microscopy revealed that although apoptosis of outer root sheath keratinocytes produces normal hair follicle involution (catagen), increased levels of apoptosis, necrosis, and dark-cell formation appear to be related to the pathology of alopecia areata. Although cell degeneration was generally restricted to keratinocytes of the lower follicle, melanocytes, Langerhans' and dermal papilla cells were also affected. Keratinocytic degeneration may affect layers of matrix cells in alopecia areata, unlike the apoptosis of scattered outer root sheath cells in normal catagen. The extent of cell death suggests a pathological rather than a physiological event in alopecia areata.
对急性斑秃患者毛囊中不同形式细胞变性的形态学及发生率进行了研究。除凋亡和坏死外，细胞变性的第三种形态模式——暗细胞转化也很明显。研究了15例未经治疗的急性斑秃患者及3名无脱发的正常成年人。电子显微镜检查显示，虽然外根鞘角质形成细胞的凋亡会导致正常毛囊退化（退行期），但凋亡、坏死及暗细胞形成水平的升高似乎与斑秃的病理状况有关。虽然细胞变性通常局限于毛囊下部的角质形成细胞，但黑素细胞、朗格汉斯细胞和真皮乳头细胞也会受到影响。与正常退行期散在外根鞘细胞的凋亡不同，斑秃中的角质形成细胞变性可能会影响基质细胞层。细胞死亡的程度表明斑秃是一种病理而非生理事件。
