Sessler D I
Department of Anesthesia, University of California, San Francisco 94143-0648.
Anesth Analg. 1991 Sep;73(3):300-3. doi: 10.1213/00000539-199109000-00013.
Isoflurane anesthesia in humans markedly decreases the threshold temperature triggering peripheral thermoregulatory vasoconstriction (i.e., central temperature triggering vasoconstriction). However, it is not known whether the sweating threshold remains unchanged (e.g., near 37 degrees C), decreases along with the vasoconstriction threshold, or increases during anesthetic administration. Accordingly, the hypothesis that isoflurane anesthesia increases the thermoregulatory threshold for sweating was tested. Forehead sweating was evaluated in five healthy patients given isoflurane anesthesia. The sweating threshold was prospectively defined as the distal esophageal temperature at which significant sweating was first observed. Sweating was observed in each patient at a mean central temperature of 38.3 +/- 0.3 degrees C and an end-tidal isoflurane concentration of 1.1% +/- 0.2%. The interthreshold range (difference between vasoconstriction and sweating thresholds) without anesthesia is approximately 0.5 degrees C; isoflurane anesthesia increases this range to approximately 4 degrees C.
异氟烷麻醉可显著降低触发外周体温调节性血管收缩的阈值温度（即触发血管收缩的中心温度）。然而，尚不清楚出汗阈值是保持不变（例如接近37摄氏度）、随血管收缩阈值降低，还是在麻醉给药期间升高。因此，对异氟烷麻醉会提高出汗的体温调节阈值这一假说进行了检验。对五名接受异氟烷麻醉的健康患者的额头出汗情况进行了评估。出汗阈值被前瞻性地定义为首次观察到明显出汗时的食管远端温度。在每位患者的中心温度平均为38.3±0.3摄氏度、呼气末异氟烷浓度为1.1%±0.2%时观察到出汗。未麻醉时的阈值间范围（血管收缩阈值与出汗阈值之间的差异）约为0.5摄氏度；异氟烷麻醉将该范围增加到约4摄氏度。
