Portillo Martín J A, Val Bernal F, Garijo Ayenza F, Buelta Carrillo L, Martín García B, Hernández Rodríguez R, Gutiérrez Baños J L, Correas Goméz M A, Fernández Gómez J M, Concepción Masip T
Servicio de Urología, Hospital Marqués de Valdecilla, Santander, España.
Arch Esp Urol. 1991 Apr;44(3):243-9.
A morphometric study of the tumor cell nucleus was performed in 148 cases of superficial transitional cell carcinoma of the bladder. Of these, 131 were papillary and 17 were nonpapillary tumors. Our methodology is compared with those described elsewhere. With regard to papillary tumors, the nuclear size of the internal papilla near the stroma was found to be greater than that of the external papilla near the bladder lumen. Tumor cells with internal papillary nuclear size less than or equal to 28 microns 2 appeared to have a better prognosis. Thus, nuclear measurements in this area must be performed in future studies. No conclusive data could be obtained relative to the nonpapillary tumors. For both papillary and nonpapillary tumors, the higher the histologic grade, the greater the nuclear size, the differences being statistically significant.
对148例膀胱浅表移行细胞癌进行了肿瘤细胞核形态计量学研究。其中，131例为乳头状肿瘤，17例为非乳头状肿瘤。我们的方法与其他地方描述的方法进行了比较。关于乳头状肿瘤，发现靠近基质的内乳头的核大小大于靠近膀胱腔的外乳头的核大小。内乳头核大小小于或等于28平方微米的肿瘤细胞似乎预后较好。因此，在未来的研究中必须对该区域进行核测量。关于非乳头状肿瘤，未能获得确凿的数据。对于乳头状和非乳头状肿瘤，组织学分级越高，核大小越大，差异具有统计学意义。
