Takahashi Tsutomu, Yücel Murat, Yung Alison R, Wood Stephen J, Phillips Lisa J, Berger Gregor E, Ang Anthony, Soulsby Bridget, McGorry Patrick D, Suzuki Michio, Velakoulis Dennis, Pantelis Christos
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Oct 1;32(7):1708-14. doi: 10.1016/j.pnpbp.2008.07.007. Epub 2008 Jul 15.
Abnormal neurodevelopment in midline structures such as the adhesio interthalamica (AI) has been reported in psychotic disorders, but it is unknown whether individuals at risk for the disorder share the AI findings observed in patients with florid psychosis. Magnetic resonance imaging of 162 patients with first-episode psychosis (FEP), 89 patients with chronic schizophrenia, 135 individuals at ultra high-risk (UHR) of psychosis (of whom 39 later developed psychosis), and 87 healthy controls were used to investigate the length and prevalence of the AI. The relation of the AI length to lateral ventricular enlargement was also explored. The patients with FEP and chronic schizophrenia as well as UHR individuals had a shorter AI than the controls, but there was no difference in the AI findings between the UHR individuals who did and did not subsequently develop psychosis. There was a negative correlation between the AI length and lateral ventricular volume in all the diagnostic groups. The absence of the AI was more common in the chronic schizophrenia patients when compared with all other groups. These results support the notion that the AI absence or shorter length could be a neurodevelopmental marker related to vulnerability to psychopathology, but also suggest that schizophrenia patients may manifest progressive brain changes related to ongoing atrophy of the AI after the onset.
精神病性障碍患者已被报道存在中线结构如丘脑间粘连（AI）的神经发育异常，但尚不清楚处于该疾病风险中的个体是否与处于明显精神病状态的患者具有相同的AI表现。对162例首发精神病（FEP）患者、89例慢性精神分裂症患者、135例超高风险（UHR）精神病个体（其中39例后来发展为精神病）以及87例健康对照者进行磁共振成像，以研究AI的长度和发生率。同时还探讨了AI长度与侧脑室扩大的关系。FEP患者、慢性精神分裂症患者以及UHR个体的AI均短于对照组，但后来发展为精神病和未发展为精神病的UHR个体之间的AI表现并无差异。在所有诊断组中，AI长度与侧脑室体积呈负相关。与所有其他组相比，慢性精神分裂症患者中AI缺如更为常见。这些结果支持以下观点：AI缺如或长度较短可能是与精神病理学易感性相关的神经发育标志物，但也表明精神分裂症患者在发病后可能表现出与AI持续萎缩相关的进行性脑改变。
