天然的和转化生长因子β诱导的Foxp3(+)CD4(+)CD25(+)调节性T细胞并非彼此的镜像。
Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other.
作者信息
Horwitz David A, Zheng Song Guo, Gray J Dixon
机构信息
Division of Rheumatology and Immunology, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA.
出版信息
Trends Immunol. 2008 Sep;29(9):429-35. doi: 10.1016/j.it.2008.06.005. Epub 2008 Aug 3.
Foxp3(+) CD4(+) CD25(+) regulatory cell (Treg) subsets that maintain immunologic homeostasis have been considered to be a homogeneous population of naturally occurring, thymus-derived CD4(+)CD25(+) cells (nTregs). However, similar Foxp3+ Tregs can be induced from CD25(-) precursors in vivo, and ex vivo with interleukin 2 (IL-2) and transforming growth factor beta (TGF-beta) (iTregs). These two subsets differ in their principal antigen specificities and in the T-cell receptor signal strength and co-stimulatory requirements needed for their generation. However, whether iTregs have any unique functions in vivo has been unclear. Although IL-6 can convert nTregs to Th17 cells, iTregs induced by IL-2 and TGF-beta are resistant to this cytokine and thereby might retain suppressive function at inflammatory sites. Thus, nTregs and iTregs may have different roles in the adaptive immune response.
维持免疫稳态的Foxp3(+) CD4(+) CD25(+)调节性细胞（Treg）亚群曾被认为是天然存在的、源自胸腺的CD4(+)CD25(+)细胞（nTreg）的同质群体。然而，体内可从CD25(-)前体细胞诱导出类似的Foxp3+ Treg，体外利用白细胞介素2（IL-2）和转化生长因子β（TGF-β）也可诱导产生（iTreg）。这两个亚群在主要抗原特异性以及生成所需的T细胞受体信号强度和共刺激需求方面存在差异。然而，iTreg在体内是否具有任何独特功能尚不清楚。虽然IL-6可将nTreg转化为Th17细胞，但由IL-2和TGF-β诱导的iTreg对这种细胞因子具有抗性，因此可能在炎症部位保留抑制功能。因此，nTreg和iTreg在适应性免疫反应中可能具有不同作用。
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