Department of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Kunming, China.
Division of Immunology and Rheumatology, Ohio State University Wexner Medical Center and College of Medicine, Columbus, OH, United States.
Front Immunol. 2021 Feb 19;12:574967. doi: 10.3389/fimmu.2021.574967. eCollection 2021.
Vitamin D is one of the most important nutrients required by the human body. It is a steroid hormone that plays an important role in regulating calcium and phosphorus metabolism, and bone health. Epidemiological studies have revealed a close correlation between vitamin D and many common chronic diseases. Additionally, vitamin D has recently been shown to act as an immunomodulatory hormone, and, accordingly, vitamin D deficiency was uncovered as a risk factor for autoimmune thyroid diseases, although the underlying mechanisms are still unknown. It is therefore necessary to disclose the role and mechanism of action of vitamin D in the occurrence and development of autoimmune thyroid diseases. This knowledge will help design intervention and early treatment strategies for patients with autoimmune thyroid diseases who present with low levels of vitamin D.
维生素 D 是人体所需的最重要的营养素之一。它是一种类固醇激素，在调节钙和磷代谢以及骨骼健康方面发挥着重要作用。流行病学研究表明，维生素 D 与许多常见的慢性疾病密切相关。此外，维生素 D 最近被证明是一种免疫调节激素，因此，维生素 D 缺乏被发现是自身免疫性甲状腺疾病的一个危险因素，尽管其潜在机制尚不清楚。因此，有必要揭示维生素 D 在自身免疫性甲状腺疾病的发生和发展中的作用和作用机制。这一知识将有助于为维生素 D 水平低的自身免疫性甲状腺疾病患者设计干预和早期治疗策略。
