以2,2,2-三氟乙醇为改性剂在超临界流体色谱中分析和纯化对酒精敏感的手性化合物。
Analysis and purification of alcohol-sensitive chiral compounds using 2,2,2-trifluoroethanol as a modifier in supercritical fluid chromatography.
作者信息
Byrne Neal, Hayes-Larson Eleanor, Liao Wei-Wei, Kraml Christina M
机构信息
Lotus Separations, LLC, Princeton University, Washington Road, Princeton, NJ 08544, USA.
出版信息
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Nov 1;875(1):237-42. doi: 10.1016/j.jchromb.2008.06.057.
2,2,2-Trifluoroethanol (TFE) is evaluated as an alternative modifier for the analysis and purification of alcohol-sensitive chiral compounds using supercritical fluid chromatography (SFC). Four chiral compounds, selected for their sensitivity to alcohols, in addition to a variety of standard chiral compounds were analyzed by SFC using TFE with polysaccharide and Pirkle-type chiral stationary phases (CSPs) to produce selectivities (alpha) and resolutions (Rs) as high as 1.4 and 7.2. A preparative isolation of 2-phenylglutaric anhydride was achieved using TFE as the mobile phase modifier to produce clean enantiomers.
2,2,2-三氟乙醇（TFE）被评估为一种替代改性剂，用于使用超临界流体色谱法（SFC）分析和纯化对醇敏感的手性化合物。除了各种标准手性化合物外，还选择了四种对醇敏感的手性化合物，通过SFC使用TFE与多糖和Pirkle型手性固定相（CSP）进行分析，以产生高达1.4和7.2的选择性（α）和分辨率（Rs）。使用TFE作为流动相改性剂实现了2-苯基戊二酸酐的制备分离，得到了纯净的对映体。
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