Papp-Wallace Krisztina M, Nartea Margaret, Kehres David G, Porwollik Steffen, McClelland Michael, Libby Stephen J, Fang Ferric C, Maguire Michael E
Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4965, USA.
J Bacteriol. 2008 Oct;190(19):6517-23. doi: 10.1128/JB.00772-08. Epub 2008 Aug 1.
CorA is the primary Mg(2+) channel in Salmonella enterica serovar Typhimurium. A corA mutant is attenuated in mice and defective for invasion of and replication within epithelial cells. Microarray studies show that several virulence effectors are repressed in a corA mutant strain, which ultimately manifests itself as a decrease in virulence.
CorA是鼠伤寒沙门氏菌中的主要镁离子通道。corA突变体在小鼠中减毒,并且在上皮细胞内的侵袭和复制存在缺陷。微阵列研究表明,几种毒力效应蛋白在corA突变菌株中受到抑制,这最终表现为毒力下降。