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鼠伤寒沙门氏菌的毒力需要CorA镁离子通道。

The CorA Mg2+ channel is required for the virulence of Salmonella enterica serovar typhimurium.

作者信息

Papp-Wallace Krisztina M, Nartea Margaret, Kehres David G, Porwollik Steffen, McClelland Michael, Libby Stephen J, Fang Ferric C, Maguire Michael E

机构信息

Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4965, USA.

出版信息

J Bacteriol. 2008 Oct;190(19):6517-23. doi: 10.1128/JB.00772-08. Epub 2008 Aug 1.

Abstract

CorA is the primary Mg(2+) channel in Salmonella enterica serovar Typhimurium. A corA mutant is attenuated in mice and defective for invasion of and replication within epithelial cells. Microarray studies show that several virulence effectors are repressed in a corA mutant strain, which ultimately manifests itself as a decrease in virulence.

摘要

CorA是鼠伤寒沙门氏菌中的主要镁离子通道。corA突变体在小鼠中减毒,并且在上皮细胞内的侵袭和复制存在缺陷。微阵列研究表明,几种毒力效应蛋白在corA突变菌株中受到抑制,这最终表现为毒力下降。

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本文引用的文献

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J Bacteriol. 2008 Oct;190(19):6509-16. doi: 10.1128/JB.00144-08. Epub 2008 Aug 1.
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The CorA Mg2+ transporter does not transport Fe2+.
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