大环内酯类抗生素介导的铜绿假单胞菌MexAB - OprM外排泵表达下调
Macrolide antibiotic-mediated downregulation of MexAB-OprM efflux pump expression in Pseudomonas aeruginosa.
作者信息
Sugimura Makoto, Maseda Hideaki, Hanaki Hideaki, Nakae Taiji
机构信息
Graduate School of Medical Science, Kitasato Institute University, Sagamihara, Japan.
出版信息
Antimicrob Agents Chemother. 2008 Nov;52(11):4141-4. doi: 10.1128/AAC.00511-08. Epub 2008 Aug 1.
Abstract
Macrolide antibiotics modulate the quorum-sensing system of Pseudomonas aeruginosa. We tested the effect of macrolide antibiotics on the cell density-dependent expression of the MexAB-OprM efflux pump and found that 1.0 mug/ml (MIC/6.25) of azithromycin suppressed the expression of MexAB-OprM by about 70%, with the result that the cells became two- to fourfold more susceptible to antibiotics such as aztreonam, tetracycline, carbenicillin, chloramphenicol, and novobiocin.
摘要
大环内酯类抗生素可调节铜绿假单胞菌的群体感应系统。我们测试了大环内酯类抗生素对MexAB-OprM外排泵细胞密度依赖性表达的影响，发现1.0微克/毫升（MIC/6.25）的阿奇霉素可使MexAB-OprM的表达抑制约70%，结果使细胞对氨曲南、四环素、羧苄青霉素、氯霉素和新生霉素等抗生素的敏感性提高了2至4倍。
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