β1,2-木糖基转移酶Cxt1p是将木糖掺入新型隐球菌糖鞘脂的唯一负责酶。
Beta1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids.
作者信息
Castle Sherry A, Owuor Elizabeth A, Thompson Stephanie H, Garnsey Michelle R, Klutts J Stacey, Doering Tamara L, Levery Steven B
机构信息
Department of Chemistry, University of New Hampshire, G229 Parsons Hall, Durham, New Hampshire 03824-3598, USA.
出版信息
Eukaryot Cell. 2008 Sep;7(9):1611-5. doi: 10.1128/EC.00458-07. Epub 2008 Aug 1.
Abstract
The Manalpha1,3(Xylbeta1,2)Manalpha structural motif is common to both capsular polysaccharides of Cryptococcus neoformans and to cryptococcal glycosphingolipids. Comparative analysis of glycosphingolipid structural profiles in wild-type and mutant strains showed that the Xylbeta1,2-transferase (Cxt1p) that participates in capsular polysaccharide biosynthesis is also the sole transferase responsible for adding xylose to C. neoformans glycosphingolipids.
摘要
Manα1,3(Xylβ1,2)Manα结构基序在新型隐球菌的两种荚膜多糖以及隐球菌糖鞘脂中都很常见。对野生型和突变株中糖鞘脂结构谱的比较分析表明，参与荚膜多糖生物合成的Xylβ1,2-转移酶（Cxt1p）也是负责向新型隐球菌糖鞘脂中添加木糖的唯一转移酶。
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