绝经后的认知变化：雌激素的影响
Cognitive changes after menopause: influence of estrogen.
作者信息
Henderson Victor W
机构信息
Departmentsof Health Research and Policy (Epidemiology), Stanford University, Stanford, California 94305-5405, USA.
出版信息
Clin Obstet Gynecol. 2008 Sep;51(3):618-26. doi: 10.1097/GRF.0b013e318180ba10.
Abstract
The natural menopause is not associated with substantial cognitive change. Limited clinical trial evidence suggests that estrogen-containing hormone therapy has little effect on cognition during midlife, but prompt initiation after surgical menopause may improve aspects of memory. Among older postmenopausal women, strong clinical trial evidence demonstrates that hormone initiation does not improve cognition. More limited clinical trial evidence indicates no improvement in Alzheimer symptoms, and the Women's Health Initiative Memory Study found an increase in dementia risk among older women. Observational findings of reduced Alzheimer risk may reflect early hormone use in younger women, or findings may be biased. Cognitive effects of selective estrogen receptor modulators are not yet well studied.
摘要
自然绝经与显著的认知变化无关。有限的临床试验证据表明，含雌激素的激素疗法对中年时期的认知影响不大，但在手术绝经后迅速开始使用可能会改善记忆方面。在绝经后老年女性中，有力的临床试验证据表明，开始使用激素并不能改善认知。更有限的临床试验证据表明，阿尔茨海默病症状没有改善，而且妇女健康倡议记忆研究发现老年女性患痴呆症的风险增加。关于阿尔茨海默病风险降低的观察性研究结果可能反映了年轻女性早期使用激素的情况，或者这些结果可能存在偏差。选择性雌激素受体调节剂的认知作用尚未得到充分研究。
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