Johnson Michael Edward, Murphy Paul James, Boulton Mike
Contact Lens and Anterior Eye Research Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom.
Optom Vis Sci. 2008 Aug;85(8):750-7. doi: 10.1097/OPX.0b013e318182476c.
This randomized, double-masked study compared the effectiveness of two commercially available ocular lubricants containing either 0.3% Carbomer 934 or 0.18% sodium hyaluronate (SH) in treating moderate dry eye.
Sixty-five subjects with dry eye were recruited and supplied with eyedrops containing either Carbomer or SH to use for a month. Principle outcome measures were the severity of symptoms of ocular irritation, tear break-up time without (NIBUT) and with (TBUT) fluorescein, and corneal and conjunctival staining with fluorescein and lissamine green, respectively. At the end of the experiment, subjects were also asked, on average, how many times a day they used the treatment and the duration of any post-instillation blur.
Both Carbomer and SH reduced the symptom severity and ocular surface staining, but neither had a lasting effect on NIBUT or TBUT. The treatment effects of Carbomer and SH were equivalent for symptoms, NIBUT and TBUT. However, for both corneal and conjunctival staining, SH outperformed Carbomer in improving the integrity of the ocular surface. There was no difference in the average instillation frequency of the two products. Visual disturbance after instillation of either formulation was generally short, but lengthy periods of blur were significantly more common after the use of Carbomer.
Both of the eyedrops trialled are suitable for patients with moderate dry eye, but of the two, the SH-containing treatment has marginal benefits in therapeutic efficacy and has less propensity to cause visual disturbance.
本随机双盲研究比较了两种市售眼部润滑剂的有效性，这两种润滑剂分别含有0.3%的卡波姆934或0.18%的透明质酸钠（SH），用于治疗中度干眼症。
招募了65名干眼症患者，并为其提供含卡波姆或SH的眼药水，使用一个月。主要观察指标为眼部刺激症状的严重程度、无荧光素（NIBUT）和有荧光素（TBUT）时的泪膜破裂时间，以及分别用荧光素和丽丝胺绿进行的角膜和结膜染色。在实验结束时，还平均询问了受试者每天使用该治疗的次数以及滴药后任何视物模糊的持续时间。
卡波姆和SH均降低了症状严重程度和眼表染色，但对NIBUT或TBUT均无持久影响。卡波姆和SH在症状、NIBUT和TBUT方面的治疗效果相当。然而，对于角膜和结膜染色，SH在改善眼表完整性方面优于卡波姆。两种产品的平均滴药频率没有差异。两种制剂滴药后的视觉干扰通常较短，但使用卡波姆后长时间视物模糊明显更常见。
两种试验眼药水均适用于中度干眼症患者，但在这两种药中，含SH的治疗在治疗效果方面有轻微优势，且引起视觉干扰的倾向较小。
