醛糖酰胺和N-酰基二胺衍生物的抗利什曼原虫活性。
Antileishmanial activity of aldonamides and N-acyl-diamine derivatives.
作者信息
Coimbra Elaine S, Almeida Camila G, Júnior Wilson V, Dos Reis Roberta C N, De Almeida Ana C F, Forezi Luana S M, De Almeida Mauro V, Le Hyaric Mireille
机构信息
Departamento de Parasitologia, Microbiologia e Imunologia, Instituto de CiênciasBiológicas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900, Juiz de Fora, MG, Brazil.
出版信息
ScientificWorldJournal. 2008 Jul 31;8:752-6. doi: 10.1100/tsw.2008.100.
A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obtained for compounds 10 and 15 with IC50 against L. chagasi below 5 microM.
已合成了多种亲脂性N-酰基二胺和醛糖酰胺，并测试了它们对亚马逊利什曼原虫和恰加斯利什曼原虫的体外抗增殖活性。具有一个氨基的核糖酰胺对寄生虫生长表现出良好到中等程度的抑制作用。化合物10和15对恰加斯利什曼原虫的IC50低于5 microM，取得了最佳结果。
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