Abdur Rahman Abdur Rub, Justin Gusphyl, Guiseppi-Elie Anthony
Center for Bioelectronics, Biosensors and Biochips (C3B), Clemson University, 100 Technology Drive, Anderson, SC 29625, USA.
Biomed Microdevices. 2009 Feb;11(1):75-85. doi: 10.1007/s10544-008-9211-6.
A complete electrochemical cell-on-a-chip that uses the MicroDisc Electrode Array (MDEA) working electrode (WE) design was evaluated for eventual intramuscular implantation for the continuous amperometric monitoring of glucose and lactate in an animal trauma model. The microfabricated ECC MDEA5037 comprises two discrete electrochemical cells-on-a-chip (ECCs), each with a reference, counter, and MDEA working electrode. Each MDEA comprises 37 microdiscs (diameter = 50 microm) arranged in a Hexagonal Closed Packed (HCP) arrangement with a center to center distance (d) of 100 microm. Cyclic Voltammetry (CV) and Electrical Impendence Spectroscopy (EIS) reveals that this device scales in its interfacial properties with a corresponding MDEA 050 device that comprises 5,184 microdiscs. Parallel development of miniaturized mixed-signal integrated electronics for wireless reprogramming, data acquisition and communication addresses the key issues involved in developing measurement electronics, AD/DA processing, power management and telemetry for implantable amperometric biosensors. A generalized electronics platform based on the Texas Instruments TI NC01101 chip has been developed that may be readily applied to many types of biotransducers with minor modifications.
一种完整的片上电化学电池，采用微盘电极阵列（MDEA）工作电极（WE）设计，针对动物创伤模型中葡萄糖和乳酸的连续安培监测进行了最终肌肉内植入评估。微加工的ECC MDEA5037包含两个离散的片上电化学电池（ECC），每个都有一个参比电极、对电极和MDEA工作电极。每个MDEA由37个微盘（直径 = 50微米）组成，排列成六方密堆积（HCP）结构，中心距（d）为100微米。循环伏安法（CV）和电化学阻抗谱（EIS）表明，该装置的界面特性与包含5184个微盘的相应MDEA 050装置成比例。用于无线重新编程、数据采集和通信的小型化混合信号集成电子器件的并行开发解决了为可植入安培生物传感器开发测量电子器件、AD/DA处理、电源管理和遥测所涉及的关键问题。已经开发了一种基于德州仪器TI NC01101芯片的通用电子平台，只需进行少量修改即可轻松应用于多种类型的生物传感器。
