Groth G, Freundt K J
Institut für Pharmakologie und Toxikologie, Fakultät für Klinische Medizin Mannheim, Universität Heidelberg.
Blutalkohol. 1991 May;28(3):166-73.
Adult female SPF rats (strain: Sprague-Dawley) were treated with 790 mg ethanol/kg body weight by intraperitoneal injection 30 minutes after the beginning of a 5-hr-inhalation of about 1,000 ppm n-butyl acetate in air via a tracheotomy tube (under urethane anesthesia). The elimination of the ethanol from blood which was increased to about 24 mmol/l (1.1%, g/v) was not delayed during the initial linear phase as compared to control (ethanol treatment without inhalation of n-butyl acetate). During inhalation approximately 24 mumol n-butyl acetate/l were measured in blood without ethanol treatment and approximately 52 mumol n-butanol/l as a metabolite of n-butyl acetate. The n-butanol content in blood was doubled under ethanol treatment. This increase is explained by substrate competition of both alcohols at the alcohol dehydrogenase with ethanol excess.
成年雌性SPF大鼠（品系：Sprague-Dawley）在通过气管切开管（在氨基甲酸乙酯麻醉下）吸入约1000 ppm乙酸正丁酯5小时后30分钟，经腹腔注射790 mg乙醇/千克体重。与对照组（未吸入乙酸正丁酯的乙醇处理）相比，在初始线性阶段，血液中乙醇消除量增加至约24 mmol/l（1.1%，g/v）并未延迟。在吸入过程中，未进行乙醇处理的血液中乙酸正丁酯含量约为24 μmol/l，作为乙酸正丁酯代谢产物的正丁醇含量约为52 μmol/l。在乙醇处理下，血液中正丁醇含量翻倍。这种增加是由于两种醇在乙醇过量时在乙醇脱氢酶处的底物竞争所致。
