Coelho Fernanda Matos, Reis Helton José, Nicolato Rodrigo, Romano-Silva Marco Aurélio, Teixeira Mauro Martins, Bauer Moisés Evandro, Teixeira Antonio Lucio
Group of Neuroimmunology, Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Neuroimmunomodulation. 2008;15(2):140-4. doi: 10.1159/000148197. Epub 2008 Aug 5.
Activation of the cytokine systems may be involved in the neuropathological changes occurring in the central nervous systems of schizophrenic patients. However, associations between the levels of cytokines and the severity of symptoms have not been completely established.
It was the aim of this study to evaluate serum levels of tumor necrosis factor (TNF)-alpha and their soluble receptors (sTNFR) in schizophrenic patients and healthy controls.
Forty male institutionalized schizophrenic patients (mean age +/- SD, 52.3 +/- 9.9 years) and 20 asymptomatic matched controls were recruited. The severity of symptoms was assessed using the Brief Psychiatric Rating Scale, the Positive and Negative Syndrome Scale and the Abnormal Involuntary Movement Scale. Serum levels of cytokines were measured by ELISAs.
Serum levels of sTNFR1 and sTNFR2 were increased in schizophrenic patients when compared with controls (all p < 0.05), but there was no difference in TNF-alpha levels. There was no correlation between the length of disease/hospitalization or the severity of symptoms and the serum levels of these molecules.
Inflammatory markers are increased in schizophrenia but they do not correlate with symptom severity.
细胞因子系统的激活可能与精神分裂症患者中枢神经系统中发生的神经病理变化有关。然而，细胞因子水平与症状严重程度之间的关联尚未完全确立。
本研究旨在评估精神分裂症患者和健康对照者血清中肿瘤坏死因子（TNF）-α及其可溶性受体（sTNFR）的水平。
招募了40名住院男性精神分裂症患者（平均年龄±标准差，52.3±9.9岁）和20名无症状匹配对照者。使用简明精神病评定量表、阳性和阴性症状量表以及异常不自主运动量表评估症状严重程度。通过酶联免疫吸附测定法测量血清细胞因子水平。
与对照组相比，精神分裂症患者血清中sTNFR1和sTNFR2水平升高（所有p<0.05），但TNF-α水平无差异。疾病/住院时间长短或症状严重程度与这些分子的血清水平之间无相关性。
精神分裂症患者炎症标志物升高，但它们与症状严重程度无关。
