一名患有严重溃疡性结肠炎的18岁男性发生脑静脉血栓形成和肝素诱导的血小板减少症。
Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis.
作者信息
Thorsteinsson Gudrun Scheving, Magnussson Maria, Hallberg Lena M, Wahlgren Nils Gunnar, Lindgren Fredrik, Malmborg Petter, Casswall Thomas H
机构信息
Division of Paediatric Gastroenterology, Hepatology & Nutrition, B57 Karolinska University Hospital Stockholm Se-141 86, Sweden.
出版信息
World J Gastroenterol. 2008 Jul 28;14(28):4576-9. doi: 10.3748/wjg.14.4576.
Abstract
The risk of thromboembolism is increased in inflammatory bowel disease and its symptoms may be overlooked. Furthermore, its treatment can be complex and is not without complications. We describe a case of an adolescent boy who developed a cerebral sinus venous thrombosis during a relapse of his ulcerative colitis and who, while on treatment with heparin, developed heparin-induced thrombocytopenia (HIT). The treatment was then switched to fondaparinux, a synthetic and selective inhibitor of activated factor X.
摘要
炎症性肠病患者发生血栓栓塞的风险增加，其症状可能被忽视。此外，其治疗可能很复杂且并非没有并发症。我们描述了一例青少年男性患者，他在溃疡性结肠炎复发期间发生了脑静脉窦血栓形成，在接受肝素治疗时又出现了肝素诱导的血小板减少症（HIT）。随后治疗改为使用磺达肝癸钠，一种活化因子X的合成选择性抑制剂。
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