Aleckovic Masa, Simón Carlos
Valencia Stem Cell Bank, Centro de Investigación Principe Felipe, Valencia University, Valencia, Spain.
Reprod Biomed Online. 2008 Aug;17(2):270-80. doi: 10.1016/s1472-6483(10)60206-4.
Transplantation of pluripotent embryonic stem cells (ESC) into immune-deficient mice results in the formation of complex teratomas consisting of derivatives from all three germ layers. The highly sophisticated tissue organization found therein resembles structures normally found in the embryo and adult. Used as a functional proof of pluripotency of ESC, teratoma characterization has been restricted to identification of derivatives from all three germ layers. This paper aims to provide a thoughtful analysis of teratoma formation from a range of stem cells on the basis of published information, in an attempt to gain insight into tissue development during embryogenesis and provide a useful model for studying human development in normal as well as abnormal situations and toxicity studies. Furthermore, it is believed that studies on teratomas might lead to novel approaches in many research areas, including oncology and bioengineering.
将多能胚胎干细胞（ESC）移植到免疫缺陷小鼠体内会导致形成由所有三个胚层衍生物组成的复杂畸胎瘤。其中发现的高度复杂的组织结构类似于胚胎和成人中正常发现的结构。作为ESC多能性的功能证据，畸胎瘤特征鉴定仅限于识别所有三个胚层的衍生物。本文旨在根据已发表的信息，对一系列干细胞形成畸胎瘤的情况进行深入分析，以深入了解胚胎发育过程中的组织发育，并为研究正常和异常情况下的人类发育以及毒性研究提供有用的模型。此外，人们认为对畸胎瘤的研究可能会在包括肿瘤学和生物工程在内的许多研究领域带来新方法。
