基因调控：限度内的边界

Gene regulation: boundaries within limits.

作者信息

Payankaulam Sandhya, Arnosti David N

机构信息

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824-1319, USA.

出版信息

Curr Biol. 2008 Aug 5;18(15):R653-R655. doi: 10.1016/j.cub.2008.06.040.

DOI:10.1016/j.cub.2008.06.040

PMID:18682204

Abstract

Quantitative measurements of the Hunchback transcription factor in Drosophila embryos show that its target genes can respond with a high degree of precision to the exact level of the protein, simulating a continuous, analog readout, while other target genes show a combinatorial effect, resembling a Boolean logic element.

摘要

对果蝇胚胎中驼背转录因子的定量测量表明，其靶基因能够以高度的精确性对蛋白质的确切水平做出反应，模拟出连续的模拟读数，而其他靶基因则表现出组合效应，类似于布尔逻辑元件。