Koutroubakis Ioannis E
Am J Gastroenterol. 2008 Sep;103(9):2281-3. doi: 10.1111/j.1572-0241.2008.02060.x. Epub 2008 Aug 5.
There is evidence that thromboembolism as a disease-specific extraintestinal manifestation of inflammatory bowel disease (IBD) is developed as the result of multiple interactions between acquired and genetic risk factors. An imbalance of procoagulant, anticoagulant, and fibrinolitic factors predisposing to thrombosis has been reported by several studies in patients with IBD. The study by Nguyen and Sam demonstrates that hospitalized IBD patients have higher prevalence of venous thromboembolism and a more than two-fold excess of mortality compared with non-IBD hospitalized patients. When the findings from this large study are combined with previous data, they suggest that thromboembolism is a significant cause of extraintestinal morbidity and mortality in IBD patients with a higher risk during hospitalization.
有证据表明，作为炎症性肠病（IBD）特定疾病的肠外表现，血栓栓塞是获得性和遗传风险因素之间多重相互作用的结果。多项针对IBD患者的研究报告称，促凝、抗凝和纤溶因子失衡易导致血栓形成。阮和萨姆的研究表明，与非IBD住院患者相比，住院IBD患者静脉血栓栓塞的患病率更高，死亡率高出两倍多。当这项大型研究的结果与先前的数据相结合时，表明血栓栓塞是IBD患者肠外发病和死亡的重要原因，住院期间风险更高。
