胸腺迁出：T细胞何时以及如何离开“家园”。
Thymic emigration: when and how T cells leave home.
作者信息
Weinreich Michael A, Hogquist Kristin A
机构信息
Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
出版信息
J Immunol. 2008 Aug 15;181(4):2265-70. doi: 10.4049/jimmunol.181.4.2265.
Abstract
The thymus supports the differentiation of multiple distinct T cell subsets that play unique roles in the immune system. CD4 and CD8 alpha/beta T cells, gamma/delta T cells, NKT cells, regulatory T cells, and intraepithelial lymphocytes all develop in the thymus and must leave it to provide their functions elsewhere in the body. This article will review recent research indicating differences in the time and migration patterns of T cell subsets found in the thymus. Additionally, we review current understanding of the molecules involved in thymocyte emigration, including the sphingolipid receptor S1P(1) and its regulation by the Krüppel-like transcription factor KLF2.
摘要
胸腺支持多种不同T细胞亚群的分化，这些亚群在免疫系统中发挥着独特作用。CD4和CD8α/β T细胞、γ/δ T细胞、自然杀伤T细胞、调节性T细胞和上皮内淋巴细胞均在胸腺中发育，且必须离开胸腺才能在身体其他部位发挥其功能。本文将综述近期的研究，这些研究表明胸腺中发现的T细胞亚群在时间和迁移模式上存在差异。此外，我们还将综述目前对胸腺细胞迁出所涉及分子的理解，包括鞘脂受体S1P(1)及其受Krüppel样转录因子KLF2的调控。
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