Doucet Eric
School of Human Kinetics, University of Ottawa, Ontario, Canada.
Curr Opin Clin Nutr Metab Care. 2008 Sep;11(5):645-50. doi: 10.1097/MCO.0b013e32830ab9c9.
To discuss the contribution of gut peptides to the improved appetite control that results from obesity surgery.
The treatment options for morbid obesity are few, and bariatric interventions have become a common intervention to treat large excesses in adiposity. The mechanisms explaining the large weight losses and the notable long-term maintenance that characterize bariatric interventions have intrigued researchers for a few decades. One of these mechanisms may entail the altered secretion pattern of appetite-related gut peptides. In fact, an increasing number of studies have highlighted the exaggerated nutrient-stimulated response of some of these anorectic hormones, namely peptide YY and glucagon-like peptide-1, along with a down-regulation of ghrelin, the only orexigenic hormone known in humans. Among most recent findings, a suboptimal gut peptide response was reported in poor responders to bypass surgery. In summary, results currently available have brought us closer to understanding the link between the altered gut peptide secretion and the improved appetite control resulting from obesity surgery.
The surge of literature related to the exaggerated nutrient-stimulated response of gut peptides after bypass intervention provides increasing support for the role of some of these hormones in the long-term success rates of obesity surgery.
探讨肠道肽对肥胖手术所致食欲控制改善的作用。
病态肥胖的治疗选择有限，减肥手术已成为治疗严重肥胖的常见干预措施。几十年来，解释减肥手术显著的体重减轻和长期维持效果的机制一直吸引着研究人员。其中一种机制可能涉及与食欲相关的肠道肽分泌模式的改变。事实上，越来越多的研究强调了其中一些厌食激素（即肽YY和胰高血糖素样肽-1）对营养刺激的反应增强，同时胃饥饿素（人类已知的唯一促食欲激素）分泌下调。在最近的研究结果中，旁路手术反应不佳者被报道存在肠道肽反应欠佳的情况。总之，目前可得的结果使我们更接近于理解肠道肽分泌改变与肥胖手术所致食欲控制改善之间的联系。
关于旁路干预后肠道肽对营养刺激反应增强的文献激增，为其中一些激素在肥胖手术长期成功率中的作用提供了越来越多的支持。
