Molina R, Filella X, Bruix J, Mengual P, Bosch J, Calvet X, Jo J, Ballesta A M
Laboratory of Clinical Biochemistry, Hospital Clinico Provincial, School of Medicine, Barcelona, Spain.
Clin Chem. 1991 Aug;37(8):1379-83.
Serum concentrations of cancer antigen 125 (CA 125) were determined for 373 patients with various liver diseases: 57 with acute hepatitis, 57 with chronic hepatitis, 244 with liver cirrhosis (86 compensated and 158 decompensated), and 15 with primary liver cancer. The antigen was measured simultaneously in the serum and ascitic fluid of 46 of the patients with liver cirrhosis and sequentially in the serum and ascitic fluid of another 25 cirrhotics treated with paracentesis and (or) diuretics. Abnormal results for CA 125 were detected in sera from 4% of the patients with acute or chronic hepatitis, 60% of the patients with liver cirrhosis, and 67% of the patients with primary liver cancer. The main factor associated with abnormal serum concentrations of this antigen was the presence of ascites, with pathological CA 125 values in 94% of patients with ascites without jaundice (mean 566 +/- 528 arb. units/mL), compared with only 40% of patients with jaundice and without ascites (mean 40.1 +/- 28.5 arb. units/mL) (P less than 0.001). High concentrations of CA 125 were mainly associated with spontaneous bacterial peritonitis. The serum concentration of CA 125 decreased after treatment with paracentesis, but increased in patients treated with diuretics rather than paracentesis. The release of this antigen in liver cirrhosis appears to be independent of the liver disorder and, rather, results from peritoneal synthesis of this antigen.
对373例患有各种肝脏疾病的患者测定了癌抗原125（CA 125）的血清浓度：57例急性肝炎患者、57例慢性肝炎患者、244例肝硬化患者（86例代偿期和158例失代偿期）以及15例原发性肝癌患者。对46例肝硬化患者同时测定了血清和腹水中的该抗原，并对另外25例接受腹腔穿刺和（或）利尿剂治疗的肝硬化患者的血清和腹水进行了连续测定。急性或慢性肝炎患者血清中CA 125检测结果异常的占4%，肝硬化患者中占60%，原发性肝癌患者中占67%。与该抗原血清浓度异常相关的主要因素是腹水的存在，无黄疸腹水患者中94%的CA 125值呈病理性（平均566±528任意单位/毫升），而黄疸无腹水患者中仅40%（平均40.1±28.5任意单位/毫升）（P＜0.001）。高浓度的CA 125主要与自发性细菌性腹膜炎有关。腹腔穿刺治疗后CA 125的血清浓度下降，但使用利尿剂而非腹腔穿刺治疗的患者其浓度升高。肝硬化患者中该抗原的释放似乎与肝脏疾病无关，而是由该抗原的腹膜合成所致。
