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蛇毒抑制剂与新型疗法的开发。

Inhibitors of snake venoms and development of new therapeutics.

机构信息

Natural Toxins Research Center, College of Arts and Sciences, Texas A&M University-Kingsville, Kingsville, Texas, USA.

出版信息

Immunopharmacol Immunotoxicol. 2008;30(4):647-78. doi: 10.1080/08923970802279019.

Abstract

Natural inhibitors of snake venoms play a significant role in the ability to neutralize the degradation effects induced by venom toxins. It has been known for many years that animal sera and some plant extracts are competent in neutralizing snake venoms. The purpose of this review is to highlight the recent work that has been accomplished with natural inhibitors of snake venoms as well as revisiting the past research including those found in plants. The biomedical value of these natural inhibitors can lead to the development of new therapeutics for an assortment of diseases as well as contributing to efficient antivenoms for the treatment of ophidic accidents.

摘要

天然蛇毒抑制剂在中和毒液毒素诱导的降解作用方面发挥着重要作用。多年来,人们已经知道动物血清和一些植物提取物能够有效中和蛇毒。本文综述的目的是强调最近在天然蛇毒抑制剂方面所取得的工作进展,同时回顾过去的研究,包括植物来源的抑制剂。这些天然抑制剂的生物医学价值可用于开发治疗多种疾病的新疗法,并为治疗蛇咬伤事故提供更有效的抗蛇毒血清。

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