在通过高效液相色谱法分析糖化血红蛋白（A1c）的过程中检测到两种异常血红蛋白，即曼尼托巴血红蛋白（Hb Manitoba）和库沙塔血红蛋白（Hb G-Coushatta）。
Detection of two abnormal hemoglobins, Hb Manitoba and Hb G-Coushatta, during analysis of glycohemoglobin (A1c) by high-performance liquid chromatography.
作者信息
Wong S C, Tesanovic M, Poon M C
机构信息
Department of Laboratory Medicine, Foothills Provincial General Hospital, University of Calgary, Alberta, Canada.
出版信息
Clin Chem. 1991 Aug;37(8):1456-9.
This report concerns the detection of two abnormal hemoglobins (Hb), Hb Manitoba and Hb G Coushatta, during analysis for glycohemoglobin (Hb A1c). Blood samples from two diabetic patients, analyzed for Hb A1c by HPLC, were found to contain additional Hb peaks. The presence of an abnormal Hb was confirmed in both instances by hemoglobinopathy studies. Structural studies determined the two Hb variants to be Hb Manitoba (alpha 2 102 Ser----Arg beta 2) and Hb G-Coushatta (alpha 2 beta 2 22 Glu----Ala). The significance of the presence of an abnormal Hb in Hb A1c analysis is discussed.
本报告涉及在糖化血红蛋白（Hb A1c）分析过程中检测到两种异常血红蛋白（Hb），即曼尼托巴血红蛋白（Hb Manitoba）和古夏塔血红蛋白（Hb G Coushatta）。通过高效液相色谱法（HPLC）对两名糖尿病患者的血样进行Hb A1c分析时，发现含有额外的Hb峰。在这两个病例中，均通过血红蛋白病研究证实存在异常Hb。结构研究确定这两种Hb变体分别为曼尼托巴血红蛋白（α2 102 Ser→Arg β2）和古夏塔血红蛋白（α2β2 22 Glu→Ala）。文中讨论了在Hb A1c分析中存在异常Hb的意义。
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