Langdown J V, Davidson R J, Williamson D
Department of Haematology, Addenbrooke's Hospital, Cambridge, U.K.
Hemoglobin. 1992;16(1-2):11-7. doi: 10.3109/03630269209005671.
Hb Turriff is a new hemoglobin variant which we have identified in a diabetic individual. During the determination of Hb A1c by high performance liquid chromatography, an inappropriately elevated result was found to be due to the abnormal hemoglobin chromatographing with the Hb A1c fraction. This new hemoglobin variant, Hb Turriff [alpha 99(G6)Lys----Glu], is not associated with any hematological disturbance, and family investigations indicate that it has arisen as a de novo mutation.
Hb Turriff是我们在一名糖尿病患者中发现的一种新的血红蛋白变体。在通过高效液相色谱法测定糖化血红蛋白（Hb A1c）时，发现结果异常升高是由于异常血红蛋白与Hb A1c组分一起进行色谱分离所致。这种新的血红蛋白变体，即Hb Turriff [α99(G6)赖氨酸→谷氨酸]，与任何血液学紊乱均无关联，家族调查表明它是作为一种新发突变出现的。
