Faculty of Pharmacy, Department of Pharmacy and Pharmaceutical Technology, University of Granada, Granada, Spain.
J Microencapsul. 2009 May;26(3):279-86. doi: 10.1080/02652040802312499. Epub 2008 Oct 20.
This paper assesses the supramolecular structure of nanocomposites prepared by including the anti-inflammatory drug 5-aminosalycilic acid in halloysite nanotubes. Halloysite tubes have sub-micron individual lengths with outer diameters ∼0.1 µm, as observed by FESEM. The mercury intrusion plots showed bimodal profiles with pore dimensions ∼10 and 0.06 µm. X-ray diffraction and thermogravimetric results revealed changes in the hydration form of the clay after the interaction. The groups associated to the interaction were studied by FTIR. The location of the drug in the composites was determined after uranium staining of its amino groups by X-EDS microanalysis coupled with HREM. The drug was located both inside and on the surface of the halloysite nanotubes. These results confirm the occurrence of two concomitant interaction mechanisms: rapid adsorption of 5-ASA at the external halloysite surface followed by slow adsorption of the drug inside the tubes.
本文评估了通过将抗炎药物 5-氨基水杨酸纳入埃洛石纳米管来制备纳米复合材料的超分子结构。FESEM 观察到，埃洛石管具有亚微米级的个体长度，外径约为 0.1 µm。压汞法图谱显示出具有 ∼10 和 0.06 µm 孔径的双峰分布。X 射线衍射和热重分析结果表明，粘土的水合形式在相互作用后发生了变化。通过 FTIR 研究了与相互作用相关的基团。通过 X 射线能谱微分析（EDS）与高分辨率透射电子显微镜（HREM）结合铀染色其氨基，确定了药物在复合材料中的位置。药物既位于埃洛石纳米管的内部又位于表面。这些结果证实了两种伴随的相互作用机制的发生：5-ASA 在埃洛石外部表面的快速吸附，随后药物在管内的缓慢吸附。
