Hernández Félix, Avila Jesús
Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Madrid, Spain.
J Alzheimers Dis. 2008 Aug;14(4):449-52. doi: 10.3233/jad-2008-14414.
There is controversy in some neurodegenerative disorders whether the presence of aberrant aggregates in a neuron could have a toxic or a protective effect. In some disorders like in encephalopathies (prion disease), protein aggregates are toxic for the neuron. In other disorders, like Huntington disease, a protective role has been suggested for the aggregates of huntingtin. In this paper, we review the role of tau aggregation and hypothesize that tau aggregates could have an insufficient protective role in damaged neurons.
在一些神经退行性疾病中，关于神经元中异常聚集体的存在是具有毒性还是保护作用存在争议。在某些疾病中，如脑病（朊病毒病），蛋白质聚集体对神经元有毒性。在其他疾病中，如亨廷顿舞蹈症，亨廷顿蛋白聚集体被认为具有保护作用。在本文中，我们回顾了tau蛋白聚集的作用，并推测tau蛋白聚集体在受损神经元中的保护作用可能不足。
