Ring H A, Heller A J, Marshall W J, Johnson A L, Reynolds E H
Department of Neurology, King's College Hospital, London, U.K.
Epilepsy Res. 1991 Apr;8(3):241-4. doi: 10.1016/0920-1211(91)90070-v.
In newly diagnosed adult patients with epilepsy followed prospectively on monotherapy, carbamazepine and phenytoin were associated with a fall in plasma uric acid, but sodium valproate and phenobarbitone were associated with a rise in plasma uric acid. The mechanisms and significance of these findings are discussed.
在对新诊断的成年癫痫患者进行前瞻性单药治疗随访时,卡马西平和苯妥英钠与血浆尿酸水平下降有关,但丙戊酸钠和苯巴比妥与血浆尿酸水平升高有关。本文讨论了这些发现的机制和意义。