临床实践中总抗惊厥血清水平和游离抗惊厥血清水平的应用。
Use of total and free anticonvulsant serum levels in clinical practice.
作者信息
Beran R G, Lewis J H, Nolte J L, Westwood A P
出版信息
Clin Exp Neurol. 1985;21:69-77.
PMID:3939613
Abstract
Total and free (unbound) anticonvulsant drug levels in serum (361 analyses) were measured in a series of 117 patients who attended for routine management of epilepsy. Comparison of predetermined therapeutic ranges for the two types of level demonstrated disagreement in as many as 30% of assessments. The clinical significance of this finding is discussed and wider acceptance of the use of free drug levels in the management of epilepsy is advocated.
摘要
对117例前来接受癫痫常规治疗的患者进行了血清中抗惊厥药物总含量及游离（未结合）含量的测定（共361次分析）。对这两种含量的预定治疗范围进行比较后发现，多达30%的评估结果存在差异。本文讨论了这一发现的临床意义，并提倡在癫痫治疗中更广泛地采用游离药物含量测定。
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