Aono Shigetoshi
Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Japan.
Dalton Trans. 2008 Jun 28(24):3137-46. doi: 10.1039/b802070c. Epub 2008 Mar 17.
Diatomic gas molecules such as O2, CO and NO act as signaling molecules in many biological systems, where metal-containing gas sensor proteins sense their effector gas molecules by using prosthetic groups such as heme, iron-sulfur clusters and non-heme iron as the active center for gas sensing. When the gas sensor proteins sense their effector gas molecules, intramolecular and intermolecular signal transductions take place to regulate many physiological functions including gene expression, aerotaxis, and change in metabolic pathways, etc. The metal-containing prosthetic groups in these sensor proteins play a crucial role for selective sensing of their effectors. In this perspective, I will discuss the structure and function of some O2-, CO- and NO-sensor proteins, especially focussing on the structural, biochemical and biophysical properties of the active centers of these sensor proteins.
双原子气体分子，如O2、CO和NO，在许多生物系统中充当信号分子，其中含金属的气体传感蛋白通过使用血红素、铁硫簇和非血红素铁等辅基作为气体传感的活性中心来感知其效应气体分子。当气体传感蛋白感知其效应气体分子时，会发生分子内和分子间信号转导，以调节许多生理功能，包括基因表达、趋氧性和代谢途径的变化等。这些传感蛋白中的含金属辅基对其效应物的选择性传感起着至关重要的作用。从这个角度出发，我将讨论一些O2、CO和NO传感蛋白的结构和功能，尤其关注这些传感蛋白活性中心的结构、生化和生物物理特性。
