局灶节段性肾小球硬化症并发孤立肾

Focal segmental glomerulosclerosis complicating solitary kidney.

作者信息

Oshiro Yoshiyuki, Umena Sachio, Noda Masatoshi

机构信息

Department of Internal Medicine, Kawasaki Medical School Kawasaki Hospital, 2-1-80 Nakasange, Okayama, Japan.

出版信息

Clin Exp Nephrol. 2009 Feb;13(1):81-4. doi: 10.1007/s10157-008-0076-z. Epub 2008 Aug 9.

DOI:10.1007/s10157-008-0076-z

PMID:18688570

Abstract

A 78-year old woman with complicating solitary kidney had nephrotic syndrome. Renal biopsy specimens showed focal segmental glomerulosclerosis (FSGS). First, the patient was treated with angiotensin receptor blocker (ARB) and angiotensin converting enzyme inhibitor (ACEI). Proteinuria decreased from 10 to 6 g/day, but overall the nephrotic syndrome did not improve. Additional treatment with prednisolone and cyclosporine reduced proteinuria to less than 1.0 g/day. We report that combination therapy with ARB, ACEI, prednisolone, and cyclosporine was successful for FSGS complicating solitary kidney.

摘要

一名患有复杂性单肾的78岁女性患有肾病综合征。肾活检标本显示局灶节段性肾小球硬化（FSGS）。首先，患者接受了血管紧张素受体阻滞剂（ARB）和血管紧张素转换酶抑制剂（ACEI）治疗。蛋白尿从每天10克降至6克，但总体上肾病综合征并未改善。泼尼松龙和环孢素的额外治疗使蛋白尿降至每天1.0克以下。我们报告，ARB、ACEI、泼尼松龙和环孢素联合治疗对伴有单肾的FSGS是成功的。