Orakwe J C, Chukwujama N O, Egbunam B E
Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, Nnewi.
Niger J Clin Pract. 2008 Mar;11(1):1-4.
To study postorchiectomy anaemia in black Nigerian patients who had bilateral orchiectomy for advanced carcinoma of the prostate. Anaemia has been observed in similar studies done on Caucasians and non-black patients in non-tropical environments
Consecutive patients with advanced carcinoma of the prostate who were managed by the authors over a four-year period, and who were treated with bilateral orchiectomy were prospectively studied. They also satisfied the set criteria for inclusion in the study.
Thirty-six patients were studied. The mean age was 71 years (SD = 7.6). Preoperative white blood cell count with blood film examination, and serum urea and creatinine were within normal limits and remained so for the duration of the study. The mean value of the haemoglobin concentration dropped significantly from 11.9 g/dl to 10.1 g/dl at six months (p < 0.005). The prostate specific antigen decreased from a mean preoperative value of 62.2 ng/ml (SD = 58.6) to a mean postoperative nadir of 2.9 ng/ml (SD = 1.3) after three months.
In Nigerians, there is a statistically significant decrease in the heamoglobin concentration after bilateral orchiectomy. This should be closely monitored, and treated when indicated.
研究因晚期前列腺癌接受双侧睾丸切除术的尼日利亚黑人患者术后贫血情况。在非热带环境中对高加索人和非黑人患者进行的类似研究中已观察到贫血现象。
对作者在四年期间管理的、接受双侧睾丸切除术治疗的晚期前列腺癌连续患者进行前瞻性研究。他们还满足纳入该研究的既定标准。
研究了36例患者。平均年龄为71岁（标准差 = 7.6）。术前白细胞计数及血涂片检查、血清尿素和肌酐均在正常范围内，且在研究期间一直保持正常。血红蛋白浓度平均值在6个月时从11.9 g/dl显著降至10.1 g/dl（p < 0.005）。前列腺特异性抗原在术后三个月从术前平均62.2 ng/ml（标准差 = 58.6）降至术后最低平均2.9 ng/ml（标准差 = 1.3）。
在尼日利亚人当中，双侧睾丸切除术后血红蛋白浓度有统计学意义的下降。对此应密切监测，并在有指征时进行治疗。
