洪都拉斯特古西加尔巴儿童登革出血热病例的体液免疫反应。

Humoral immune response of dengue hemorrhagic fever cases in children from Tegucigalpa, Honduras.

作者信息

De Rivera Ivette Lorenzana, Parham Leda, Murillo Wendy, Moncada Walter, Vazquez Susana

机构信息

Department of Microbiology, National Autonomous University of Honduras, Tegucigalpa, Honduras.

出版信息

Am J Trop Med Hyg. 2008 Aug;79(2):262-6.

PMID:18689634

Abstract

The humoral immune response in Honduran dengue hemorrhagic fever (DHF) hospitalized pediatric cases from the epidemics of 2004 and 2005 was studied in sera collected from 5 to 7 days of fever onset. A total of 145 cases were included in the study: 40 classified as primary with DHF Grade I or II and 86 classified as secondary; from them, 73 were DHF Grade I or II and 13 were dengue shock syndrome (DSS) Grade III or IV. The highest number of primary cases was found in children < 1 year of age. The highest number of secondary cases was observed in children between 5 and 10 years of age. The IgA values showed a statistically significant difference between primary and secondary groups. The relationship between antibody responses and severity grade is discussed. This is the first study related to the humoral immune response and severity grade in DHF cases in Honduran children.

摘要

对2004年和2005年疫情期间洪都拉斯登革出血热（DHF）住院儿童病例的体液免疫反应进行了研究，研究对象为发热开始5至7天采集的血清。该研究共纳入145例病例：40例归类为原发性DHF I级或II级，86例归类为继发性；其中，73例为DHF I级或II级，13例为登革休克综合征（DSS）III级或IV级。原发性病例数量最多的是年龄小于1岁的儿童。继发性病例数量最多的是5至10岁的儿童。IgA值在原发性和继发性组之间存在统计学上的显著差异。讨论了抗体反应与严重程度分级之间的关系。这是第一项关于洪都拉斯儿童DHF病例体液免疫反应和严重程度分级的研究。