过去三十年美洲登革热的流行病学：令人担忧的现实。
The epidemiology of dengue in the americas over the last three decades: a worrisome reality.
机构信息
Dengue Regional Program, Pan American Health Organization (PAHO), Panama, Republic of Panama.
出版信息
Am J Trop Med Hyg. 2010 Jan;82(1):128-35. doi: 10.4269/ajtmh.2010.09-0346.
We have reported the epidemic patterns of dengue disease in the Region of the Americas from 1980 through 2007. Dengue cases reported to the Pan American Health Organization were analyzed from three periods: 1980-1989 (80s), 1990-1999 (90s), and 2000-2007 (2000-7). Age distribution data were examined from Brazil, Venezuela, Honduras, and Mexico. Cases increased over time: 1,033,417 (80s) to 2,725,405 (90s) to 4,759,007 (2000-7). The highest concentrations were reported in the Hispanic Caribbean (39.1%) in the 80s shifting to the Southern Cone in the 90s (55%) and 2000-7 (62.9%). From 1980 through 1987, 242 deaths were reported compared with 1,391 during 2000-7. The most frequently isolated serotypes were DENV-1 and DENV-2 (90s) and DENV-2 and DENV-3 (2000-7). The highest incidence was observed among adolescents and young adults; dengue hemorrhagic fever incidence was highest among infants in Venezuela. Increasing dengue morbidity/mortality was observed in the Americas in recent decades.
我们曾报道过 1980 年至 2007 年美洲地区登革热的流行模式。对泛美卫生组织报告的登革热病例进行了三个时期的分析：1980-1989 年（80 年代）、1990-1999 年（90 年代）和 2000-2007 年（2000-7 年）。分析了来自巴西、委内瑞拉、洪都拉斯和墨西哥的年龄分布数据。病例数随时间增加：从 1,033,417（80 年代）增加到 2,725,405（90 年代），再增加到 4,759,007（2000-7 年）。80 年代，西班牙裔加勒比地区（39.1%）报告的病例浓度最高，90 年代转移到南锥体（55%）和 2000-7 年（62.9%）。1980 年至 1987 年报告了 242 例死亡，而 2000-7 年报告了 1,391 例。最常分离到的血清型是 DENV-1 和 DENV-2（90 年代）和 DENV-2 和 DENV-3（2000-7 年）。发病率最高的是青少年和青年；委内瑞拉婴儿的登革出血热发病率最高。在过去几十年中，美洲地区的登革热发病率/死亡率呈上升趋势。
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