慢性不可预测应激增强1型大麻素受体基因敲除小鼠对可卡因的条件性位置偏爱。
Chronic unpredictable stress enhances cocaine-conditioned place preference in type 1 cannabinoid receptor knockout mice.
作者信息
Miller Laurence L, Ward Sara J, Dykstra Linda A
机构信息
Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
出版信息
Behav Pharmacol. 2008 Sep;19(5-6):575-81. doi: 10.1097/FBP.0b013e32830ded11.
Cannabinoid signaling via the type 1 cannabinoid (CB1) receptor modulates the effects of drugs of abuse and the response to exposure to stressors. In addition, exposure to stressors can alter the effects of drugs of abuse. This study examined the effects of exposure to chronic unpredictable stress (CUS) in CB1 receptor knockout (CB1 KO) mice and their wild-type (WT) littermates, using cocaine-conditioned place preference (CPP) to compare their response to cocaine. Mice were untreated or exposed to 2 weeks of CUS. After this period, the acquisition of a cocaine CPP was examined with one of three doses (3.2, 10.0, or 17.0 mg/kg) of cocaine. Untreated CB1 KO and WT mice both acquired the cocaine CPP; however, exposure to CUS enhanced the acquisition of the cocaine CPP in CB1 KO mice, but did not significantly alter the effects of cocaine in WT mice. Taken together, these findings support earlier evidence suggesting a role for the CB1 receptor in the response to stress as well as in the effects of cocaine.
通过1型大麻素（CB1）受体的大麻素信号传导调节滥用药物的作用以及对应激源暴露的反应。此外，暴露于应激源可改变滥用药物的作用。本研究使用可卡因条件性位置偏爱（CPP）来比较CB1受体基因敲除（CB1 KO）小鼠及其野生型（WT）同窝小鼠对可卡因的反应，研究了慢性不可预测应激（CUS）暴露对它们的影响。小鼠未接受处理或暴露于2周的CUS。在此期间后，用三种剂量（3.2、10.0或17.0mg/kg）之一的可卡因检测可卡因CPP的获得情况。未处理的CB1 KO和WT小鼠均获得了可卡因CPP；然而，暴露于CUS增强了CB1 KO小鼠对可卡因CPP的获得，但未显著改变可卡因对WT小鼠的作用。综上所述，这些发现支持了早期证据，表明CB1受体在应激反应以及可卡因作用中发挥作用。
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