Kassim Faiz Mohammed, Davey Alexander J W, Tod Sophie, Rodger Jennifer, Albrecht Matthew A, Martin-Iverson Mathew T
Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Psychopharmacology Research Unit, School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.
Sci Rep. 2025 May 27;15(1):18469. doi: 10.1038/s41598-025-02280-9.
Our previous studies showed that dexamphetamine, an indirect dopamine agonist, widens Stimulus Binding Windows (BWs) in healthy subjects. The present study aimed to investigate the effect of nabilone, a synthetic cannabinoid agonist, on the BWs in a unimodal illusion: the tactile funneling illusion (TFI). The study also aimed to study the association between tactile illusion with psychometric scores. Healthy participants (n = 32) completed the TFI at various delays and distances of separation of stimuli after receiving nabilone (2-4 mg, PO) or placebo in a randomized, double-blind, counterbalanced, crossover manner. The primary illusory measures were funneling and errors of localisation (EL). Three physiological and five psychometric measurements were also performed. The results showed that nabilone decreased funneling in a delay-dependent manner (p = 0.0016), whereby funneling was reduced at 0 ms (p = 0.01). Nabilone also significantly reduced EL in a distance-dependent manner (p = 0.038). Nabilone increased ratings on two of the five administered psychometric scales (p < 0.05), without significantly changing the overall (average) scores. However, there were associations between the overall psychometric scores and funneling under the strongest (0 ms delay) illusion condition, which is dependent on the drug condition (nabilone ρ = 0.45, p = 0.028). To conclude, unlike the effects of dexamphetamine, low activation of the cannabinoid system decreases the illusory perception of funneling, with narrowing spatial BWs.
我们之前的研究表明，间接多巴胺激动剂右苯丙胺可拓宽健康受试者的刺激结合窗口（BW）。本研究旨在调查合成大麻素激动剂纳布啡对单峰错觉——触觉漏斗错觉（TFI）中BW的影响。该研究还旨在探究触觉错觉与心理测量分数之间的关联。健康参与者（n = 32）在以随机、双盲、平衡、交叉方式接受纳布啡（2 - 4毫克，口服）或安慰剂后，在不同的刺激延迟和间隔距离下完成TFI。主要的错觉测量指标为漏斗错觉和定位误差（EL）。还进行了三项生理测量和五项心理测量。结果显示，纳布啡以延迟依赖的方式减少了漏斗错觉（p = 0.0016），即在0毫秒时漏斗错觉减少（p = 0.01）。纳布啡还以距离依赖的方式显著降低了EL（p = 0.038）。纳布啡提高了所施用的五项心理测量量表中两项的评分（p < 0.05），但未显著改变总体（平均）分数。然而，在最强（0毫秒延迟）错觉条件下，总体心理测量分数与漏斗错觉之间存在关联，这取决于药物状况（纳布啡ρ = 0.45，p = 0.028）。总之，与右苯丙胺的作用不同，大麻素系统的低激活会减少漏斗错觉的感知，同时使空间BW变窄。
