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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Iida K, Imai A, Tamaya T

Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.

Gen Pharmacol. 1991;22(3):491-3. doi: 10.1016/0306-3623(91)90011-t.

The specific bindings of estriol (E3) and estradiol-17 beta (E2) to their specific receptors were investigated in endometrial carcinoma from 7 patients and normal tissues from their respective organs or from other patients. 2. In both cytosolic and KCl-extracted fractions from them, specific binding sites for E3 and E2 were detected, demonstrating the presence of their separate receptors in human uterus-associated tissues. 3. In certain cases (6 cases) of well-differentiated adenocarcinoma, the ratio of concentration of E3 receptor to that of E2 receptor was almost equal to or higher than in other normal tissues. 4. These findings of unique localization of E3 receptor distribution may offer new insight into identification of endometrial carcinoma more likely to respond to hormonal influence or therapy.

研究了7例子宫内膜癌患者及其各自器官或其他患者正常组织中雌三醇（E3）和雌二醇-17β（E2）与其特异性受体的特异性结合情况。2. 在它们的胞质和KCl提取组分中，均检测到E3和E2的特异性结合位点，表明人子宫相关组织中存在它们各自的受体。3. 在某些（6例）高分化腺癌病例中，E3受体浓度与E2受体浓度之比几乎等于或高于其他正常组织。4. E3受体分布的独特定位的这些发现可能为更有可能对激素影响或治疗产生反应的子宫内膜癌的识别提供新的见解。

Iida K, Imai A, Tamaya T

Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.

Gen Pharmacol. 1991;22(3):491-3. doi: 10.1016/0306-3623(91)90011-t.

The specific bindings of estriol (E3) and estradiol-17 beta (E2) to their specific receptors were investigated in endometrial carcinoma from 7 patients and normal tissues from their respective organs or from other patients. 2. In both cytosolic and KCl-extracted fractions from them, specific binding sites for E3 and E2 were detected, demonstrating the presence of their separate receptors in human uterus-associated tissues. 3. In certain cases (6 cases) of well-differentiated adenocarcinoma, the ratio of concentration of E3 receptor to that of E2 receptor was almost equal to or higher than in other normal tissues. 4. These findings of unique localization of E3 receptor distribution may offer new insight into identification of endometrial carcinoma more likely to respond to hormonal influence or therapy.

研究了7例子宫内膜癌患者及其各自器官或其他患者正常组织中雌三醇（E3）和雌二醇-17β（E2）与其特异性受体的特异性结合情况。2. 在它们的胞质和KCl提取组分中，均检测到E3和E2的特异性结合位点，表明人子宫相关组织中存在它们各自的受体。3. 在某些（6例）高分化腺癌病例中，E3受体浓度与E2受体浓度之比几乎等于或高于其他正常组织。4. E3受体分布的独特定位的这些发现可能为更有可能对激素影响或治疗产生反应的子宫内膜癌的识别提供新的见解。