Al-Malaq Haya M, Al-Aqeel Sinaa A, Al-Sultan Mohammad S
Clinical Pharmacy Department, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Saudi Med J. 2008 Aug;29(8):1145-50.
To assess the feasibility of using International Classification of Disease code (ICD-9) to ascertain the prevalence, seriousness, and preventability of adverse drug reaction (ADRs).
A retrospective study between the years 1982 and 2005 was conducted at King Khaled University Hospital (KKUH), Riyadh, Saudi Arabia to examine the ICD-9 codes assigned on discharge to identify ADRs. A list of the ICD-9 codes related to ADRs were identified. These codes were entered into the hospital computer program at the study site to identify corresponding patients' medical records. The total number of patients admitted to the hospital each year was identified to calculate the prevalence of ADRs, and descriptive analysis was also conducted.
A total of 89 patients were identified and included. Drug classes commonly associated with ADR include hormones and synthetic substitutes (14.6%), followed by primary systemic agents (13.5%). Almost 50% of cases had chronic conditions and use other drugs when the ADR had occurred. The majority of the ADRs were type A (54%) preventable, while 39% were type B non preventable, and only 6% were type C occur with long term use. The prevalence per year ranged from 0.07% in 1993 to 0.003% in 1999.
Identifying ADRs causing hospital admission by using ICD-9 coding system is easy and practical. However, under or inaccurate recording of ICD-9 codes may be a limitation to the use of such an important tool.
评估使用国际疾病分类代码（ICD - 9）来确定药物不良反应（ADR）的患病率、严重程度和可预防性的可行性。
在沙特阿拉伯利雅得的哈立德国王大学医院（KKUH）进行了一项1982年至2005年的回顾性研究，以检查出院时分配的ICD - 9代码以识别ADR。确定了与ADR相关的ICD - 9代码列表。将这些代码输入研究地点的医院计算机程序中以识别相应患者的病历。确定每年入院患者的总数以计算ADR的患病率，并进行描述性分析。
共识别并纳入了89名患者。与ADR常见相关的药物类别包括激素和合成替代品（14.6%），其次是主要的全身用药（13.5%）。近50%的病例患有慢性病，在发生ADR时使用其他药物。大多数ADR为A类（54%）可预防，而39%为B类不可预防，只有6%为长期使用导致的C类。每年的患病率从1993年的0.07%到1999年的0.003%不等。
使用ICD - 9编码系统识别导致住院的ADR既简单又实用。然而，ICD - 9代码记录不足或不准确可能会限制这一重要工具的使用。
