Søgaard Mette, Schønheyder Henrik C, Riis Anders, Sørensen Henrik T, Nørgaard Mette
Department of Clinical Microbiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark.
J Am Geriatr Soc. 2008 Sep;56(9):1593-600. doi: 10.1111/j.1532-5415.2008.01855.x. Epub 2008 Aug 4.
To assess 30-day mortality from bacteremia in relation to age and comorbidity and the association between age and mortality with increasing comorbidity.
Population-based cohort study.
North Jutland County, Denmark.
Adults in medical wards with community-acquired bacteremia, 1995 to 2004.
Smoothed mortality curves and computed mortality rate ratios (MRRs) using Cox regression analysis.
Two thousand eight hundred fifty-one patients, 851 aged 15 to 64, 1,092 aged 65 to 79, and 909 aged 80 and older were included. Mortality increased linearly with age. Compared with patients younger than 65, adjusted MRRs in patients aged 65 to 79 and 80 and older were 1.5 (95% confidence interval (CI)=1.2-2.0) and 1.8 (95% CI=1.4-2.3), respectively. Mortality also increased with level of comorbidity. Compared with patients with low comorbidity, adjusted MRRs in patients with medium and high comorbidity were 1.5 (95% CI=1.2-1.8) and 1.7 (95% CI=1.4-2.2), respectively. Regardless of the level of comorbidity, MRRs were consistently higher in older than in younger patients.
Older age and greater comorbidity predicted mortality, and increasing age-related comorbidity did not explain the effect of age.
评估菌血症相关的30天死亡率与年龄及合并症的关系，以及年龄与死亡率之间随合并症增加的关联。
基于人群的队列研究。
丹麦北日德兰郡。
1995年至2004年在医疗病房患有社区获得性菌血症的成年人。
使用Cox回归分析得出平滑死亡率曲线和计算死亡率比值（MRR）。
纳入了2851例患者，其中851例年龄在15至64岁之间，1092例年龄在65至79岁之间，909例年龄在80岁及以上。死亡率随年龄呈线性增加。与65岁以下的患者相比，65至79岁和80岁及以上患者的校正MRR分别为1.5（95%置信区间（CI）=1.2 - 2.0）和1.8（95%CI = 1.4 - 2.3）。死亡率也随合并症程度增加。与合并症程度低的患者相比，合并症程度中等和高的患者校正MRR分别为1.5（95%CI = 1.2 - 1.8）和1.7（95%CI = 1.4 - 2.2）。无论合并症程度如何，老年患者的MRR始终高于年轻患者。
高龄和更高的合并症预示着死亡率，且与年龄相关的合并症增加并不能解释年龄的影响。
