小干扰RNA的内部作用机制。
An inside job for siRNAs.
作者信息
Golden Daniel E, Gerbasi Vincent R, Sontheimer Erik J
机构信息
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA.
出版信息
Mol Cell. 2008 Aug 8;31(3):309-12. doi: 10.1016/j.molcel.2008.07.008.
Abstract
Among the three main categories of small silencing RNAs in insects and mammals-siRNAs, miRNAs, and piRNAs-siRNAs were thought to arise primarily from exogenous sources, whereas miRNAs and piRNAs arise from endogenous loci. Recent work in flies and mice reveals several classes of endogenous siRNAs (endo-siRNAs) that contribute to functions previously reserved for miRNAs and piRNAs, including gene regulation and transposon suppression.
摘要
在昆虫和哺乳动物的三类主要小干扰RNA（siRNA、miRNA和piRNA）中，siRNA被认为主要来源于外源，而miRNA和piRNA则来源于内源基因座。近期在果蝇和小鼠中的研究发现了几类内源性siRNA（endo-siRNA），它们具有以前认为只有miRNA和piRNA才有的功能，包括基因调控和转座子抑制。
相似文献
1
An inside job for siRNAs.小干扰RNA的内部作用机制。
Mol Cell. 2008 Aug 8;31(3):309-12. doi: 10.1016/j.molcel.2008.07.008.
2
Transposon defense by endo-siRNAs, piRNAs and somatic pilRNAs in Drosophila: contributions of Loqs-PD and R2D2.果蝇中内源性小干扰RNA、Piwi相互作用RNA和体细胞Piwi相互作用RNA介导的转座子防御：Loqs-PD和R2D2的作用
PLoS One. 2014 Jan 13;9(1):e84994. doi: 10.1371/journal.pone.0084994. eCollection 2014.
3
The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC.果蝇RNA甲基转移酶DmHen1可修饰生殖系piRNA和RISC中的单链siRNA。
Curr Biol. 2007 Jul 17;17(14):1265-72. doi: 10.1016/j.cub.2007.06.030. Epub 2007 Jun 28.
4
Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform.果蝇内源性小干扰RNA的加工依赖于一种特定的Loquacious同工型。
RNA. 2009 Oct;15(10):1886-95. doi: 10.1261/rna.1611309. Epub 2009 Jul 27.
5
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes.源自天然形成双链RNA的内源性小干扰RNA调控小鼠卵母细胞中的转录本。
Nature. 2008 May 22;453(7194):539-43. doi: 10.1038/nature06908. Epub 2008 Apr 10.
6
Endogenous siRNAs and piRNAs derived from transposable elements and genes in the malaria vector mosquito Anopheles gambiae.源自疟蚊冈比亚按蚊转座元件和基因的内源性小干扰RNA和Piwi相互作用RNA
BMC Genomics. 2015 Apr 10;16(1):278. doi: 10.1186/s12864-015-1436-1.
7
Diverse RNA interference strategies in early-branching metazoans.后生动物早期分支的多样化 RNA 干扰策略。
BMC Evol Biol. 2018 Nov 1;18(1):160. doi: 10.1186/s12862-018-1274-2.
8
Endogenous RNA interference provides a somatic defense against Drosophila transposons.内源性RNA干扰为果蝇转座子提供了一种体细胞防御机制。
Curr Biol. 2008 Jun 3;18(11):795-802. doi: 10.1016/j.cub.2008.05.006. Epub 2008 May 22.
9
Generation of endo-siRNAs in Xenopus laevis oocytes.
Methods Mol Biol. 2014;1173:27-32. doi: 10.1007/978-1-4939-0931-5_3.
10
Microarray analysis of Drosophila dicer-2 mutants reveals potential regulation of mitochondrial metabolism by endogenous siRNAs.果蝇 Dicer-2 突变体的微阵列分析显示内源性 siRNA 对线粒体代谢的潜在调节作用。
J Cell Biochem. 2013 Feb;114(2):418-27. doi: 10.1002/jcb.24379.
引用本文的文献
1
Leveraging RNA interference technology for selective and sustainable crop protection.利用RNA干扰技术实现选择性和可持续的作物保护。
Front Plant Sci. 2024 Dec 24;15:1502015. doi: 10.3389/fpls.2024.1502015. eCollection 2024.
2
The roles of small RNAs in rice-brown planthopper interactions.小RNA在水稻-褐飞虱相互作用中的作用。
Front Plant Sci. 2023 Nov 23;14:1326726. doi: 10.3389/fpls.2023.1326726. eCollection 2023.
3
Structural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomers.R2D2 和 Loqs-PD 协同调节 DmDcr-2 寡聚物的结构机制。
Nat Commun. 2023 Aug 26;14(1):5228. doi: 10.1038/s41467-023-40919-1.
4
Versatile Roles of Microbes and Small RNAs in Rice and Planthopper Interactions.微生物和小RNA在水稻与稻飞虱互作中的多种作用
Plant Pathol J. 2022 Oct;38(5):432-448. doi: 10.5423/PPJ.RW.07.2022.0090. Epub 2022 Oct 1.
5
RNA Interference Inhibits Molting and Wing Expansion in .RNA干扰抑制……中的蜕皮和翅发育
Insects. 2022 Jul 27;13(8):677. doi: 10.3390/insects13080677.
6
Exogenous Application of dsRNA for the Control of Viruses in Cucurbits.外源应用双链RNA控制葫芦科植物中的病毒
Front Plant Sci. 2022 Jun 27;13:895953. doi: 10.3389/fpls.2022.895953. eCollection 2022.
7
Computational analysis of sense-antisense chimeric transcripts reveals their potential regulatory features and the landscape of expression in human cells.正义-反义嵌合转录本的计算分析揭示了它们潜在的调控特征以及在人类细胞中的表达情况。
NAR Genom Bioinform. 2021 Aug 25;3(3):lqab074. doi: 10.1093/nargab/lqab074. eCollection 2021 Sep.
8
A Methodology to Study Pseudogenized lincRNAs.一种研究假基因化 lincRNAs 的方法。
Methods Mol Biol. 2021;2324:49-63. doi: 10.1007/978-1-0716-1503-4_4.
9
Unresolved Issues in RNA Therapeutics in Vascular Diseases With a Focus on Aneurysm Disease.血管疾病中RNA治疗的未解决问题——以动脉瘤疾病为重点
Front Cardiovasc Med. 2021 Apr 15;8:571076. doi: 10.3389/fcvm.2021.571076. eCollection 2021.
10
Diverse Defenses: A Perspective Comparing Dipteran Piwi-piRNA Pathways.多样的防御：比较双翅目 Piwi-piRNA 通路的一个视角。
Cells. 2020 Sep 27;9(10):2180. doi: 10.3390/cells9102180.
本文引用的文献
1
Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites.增殖细胞表达的信使核糖核酸（mRNA）具有缩短的3'非翻译区和较少的微小RNA靶位点。
Science. 2008 Jun 20;320(5883):1643-7. doi: 10.1126/science.1155390.
2
Endogenous RNA interference provides a somatic defense against Drosophila transposons.内源性RNA干扰为果蝇转座子提供了一种体细胞防御机制。
Curr Biol. 2008 Jun 3;18(11):795-802. doi: 10.1016/j.cub.2008.05.006. Epub 2008 May 22.
3
Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster.在黑腹果蝇中，两种不同的机制从双向转录中产生内源性小干扰RNA。
Nat Struct Mol Biol. 2008 Jun;15(6):581-90. doi: 10.1038/nsmb.1438. Epub 2008 May 25.
4
Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells.果蝇内源性小RNA在体细胞中与AGO2蛋白结合。
Nature. 2008 Jun 5;453(7196):793-7. doi: 10.1038/nature06938. Epub 2008 May 7.
5
An endogenous small interfering RNA pathway in Drosophila.果蝇中的内源性小干扰RNA途径。
Nature. 2008 Jun 5;453(7196):798-802. doi: 10.1038/nature07007. Epub 2008 May 7.
6
The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs.果蝇发夹RNA途径可产生内源性小干扰RNA。
Nature. 2008 Jun 5;453(7196):803-6. doi: 10.1038/nature07015. Epub 2008 May 7.
7
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes.假基因衍生的小干扰RNA调节小鼠卵母细胞中的基因表达。
Nature. 2008 May 22;453(7194):534-8. doi: 10.1038/nature06904. Epub 2008 Apr 10.
8
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes.源自天然形成双链RNA的内源性小干扰RNA调控小鼠卵母细胞中的转录本。
Nature. 2008 May 22;453(7194):539-43. doi: 10.1038/nature06908. Epub 2008 Apr 10.
9
Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells.果蝇体细胞中源自转座子和信使核糖核酸的内源性小干扰核糖核酸。
Science. 2008 May 23;320(5879):1077-81. doi: 10.1126/science.1157396. Epub 2008 Apr 10.
10
Drosophila R2D2 mediates follicle formation in somatic tissues through interactions with Dicer-1.果蝇R2D2通过与Dicer-1相互作用介导体细胞组织中的卵泡形成。
Mech Dev. 2008 May-Jun;125(5-6):475-85. doi: 10.1016/j.mod.2008.01.006. Epub 2008 Jan 24.
Zotero 插件