Hori Tomohide, Yamamoto Chiduru, Yagi Shintaro, Iida Taku, Taniguchi Kentaro, Hasegawa Takashi, Yamakado Koichiro, Hori Yukinobu, Takeda Kan, Maruyama Kazuo, Uemoto Shinji
Department of Hepato-Pancreato-Biliary Surgery and Transplantation, Kyoto University Hospital, Sakyo-ku, Kyoto, 606-8507, Japan.
Hepatobiliary Pancreat Dis Int. 2008 Aug;7(4):362-6.
Liver cirrhosis causes peculiar systemic hemodynamics, and accurate evaluation of systemic hemodynamic state is important for cirrhotic recipients who underwent living donor liver transplantation (LDLT). We investigated the clinical advantages of a novel non-invasive method for measuring systemic hemodynamic parameters using indocyanine green (ICG).
Twenty-eight LDLT recipients were evaluated. Simultaneous measurements of cardiac output (CO) using Swan-Ganz catheters and pulse dye densitometry (PDD) were performed every 12 hours after LDLT. A total of 155 sets of simultaneous CO measurements were obtained.
The CO values obtained by PDD correlated well with those obtained by the invasive catheter technique. In addition, none of the recipients developed any side-effects, and we verified the safety of repeated ICG injections. ICG is safe, even for repeated use over time in the same recipient. Moreover, PDD can measure the blood volume (BV).
Since the cirrhotic systemic hemodynamics characterized by high CO and large BV remains, even after LDLT, the ability to measure CO and BV in a non-invasive, simple and real-time manner using PDD has advantages for cirrhotic LDLT recipients.
肝硬化会导致特殊的全身血流动力学变化，对于接受活体肝移植（LDLT）的肝硬化患者，准确评估全身血流动力学状态至关重要。我们研究了一种使用吲哚菁绿（ICG）测量全身血流动力学参数的新型非侵入性方法的临床优势。
对28例接受LDLT的患者进行评估。在LDLT术后每12小时使用Swan-Ganz导管和脉搏染料密度测定法（PDD）同时测量心输出量（CO）。共获得155组同步CO测量值。
PDD获得的CO值与侵入性导管技术获得的CO值相关性良好。此外，没有患者出现任何副作用，我们验证了重复注射ICG的安全性。ICG是安全的，即使在同一患者中长期重复使用也是如此。此外，PDD可以测量血容量（BV）。
由于即使在LDLT术后，以高CO和大BV为特征的肝硬化全身血流动力学仍然存在，使用PDD以非侵入性、简单且实时的方式测量CO和BV的能力对肝硬化LDLT患者具有优势。
