骨形态发生蛋白信号的有趣的细胞外调节

Intriguing extracellular regulation of BMP signaling.

作者信息

Bier Ethan

机构信息

Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0349, USA.

出版信息

Dev Cell. 2008 Aug;15(2):176-7. doi: 10.1016/j.devcel.2008.07.012.

DOI:10.1016/j.devcel.2008.07.012

PMID:18694555

Abstract

Extracellular components of the BMP signaling pathway bind specific partners with high affinity, implying regulation by dedicated protein-protein interactions. In this and other recent issues of Developmental Cell, new results by Ambrosio et al. (and others) suggest, however, that these factors interact in more complex ways to regulate BMP signaling on a fine scale.

摘要

骨形态发生蛋白（BMP）信号通路的细胞外成分以高亲和力结合特定的伴侣分子，这意味着该通路是通过专门的蛋白质-蛋白质相互作用来进行调控的。然而，在本期以及《发育细胞》最近的其他几期杂志中，安布罗西奥等人（以及其他研究者）取得的新成果表明，这些因子以更为复杂的方式相互作用，从而在精细层面上调控BMP信号通路。