Muhizi Théoneste, Coma Véronique, Grelier Stéphane
UMR US2B, Unité des Sciences du Bois et des Biopolymères, Université Bordeaux 1, INRA, CNRS, 351, cours de la Libération F-33405 Talence, France.
Carbohydr Res. 2008 Sep 22;343(14):2369-75. doi: 10.1016/j.carres.2008.07.005. Epub 2008 Jul 15.
Various glucosylamines were synthesized from glucose and different alkyl amine compounds. These amino compounds are beta-D-glucopyranosylamine (GPA), N-ethyl-beta-D-glucopyranosylamine (EtGPA), N-butyl-beta-D-glucopyranosylamine (BuGPA), N-hexyl-beta-D-glucopyranosylamine (HeGPA), N-octyl-beta-D-glucopyranosylamine (OcGPA), N-dodecyl-beta-D-glucopyranosylamine (DoGPA), N-(2-hydroxyethyl)-beta-D-glucopyranosylamine (HEtGPA) and N,N-di(2-hydroxyethyl)-beta-D-glucopyranosylamine (DHEtGPA). They were tested for their antifungal activity against the growth of Coriolus versicolor and Poria placenta. An improvement of the antifungal activity with the increase of alkyl chain length was observed. DoGPA exhibited the best antifungal activity against both strains. It completely inhibited the fungal growth at 0.01x10(-3)molmL(-1) and 0.0075x10(-3)molmL(-1) for C. versicolor and P. placenta, respectively. For other glucosylamines higher concentrations were needed for complete inhibition of fungi.
从葡萄糖和不同的烷基胺化合物合成了多种葡糖胺。这些氨基化合物有β-D-吡喃葡萄糖胺（GPA）、N-乙基-β-D-吡喃葡萄糖胺（EtGPA）、N-丁基-β-D-吡喃葡萄糖胺（BuGPA）、N-己基-β-D-吡喃葡萄糖胺（HeGPA）、N-辛基-β-D-吡喃葡萄糖胺（OcGPA）、N-十二烷基-β-D-吡喃葡萄糖胺（DoGPA）、N-（2-羟乙基）-β-D-吡喃葡萄糖胺（HEtGPA）和N，N-二（2-羟乙基）-β-D-吡喃葡萄糖胺（DHEtGPA）。测试了它们对云芝和茯苓生长的抗真菌活性。观察到随着烷基链长度的增加抗真菌活性有所提高。DoGPA对两种菌株均表现出最佳的抗真菌活性。对于云芝和茯苓，它分别在0.01×10（-3）molmL（-1）和0.0075×10（-3）molmL（-1）时完全抑制真菌生长。对于其他葡糖胺，需要更高的浓度才能完全抑制真菌。
