Okada Taro, Kajimoto Taketoshi, Jahangeer Saleem, Nakamura Shun-ichi
Division of Biochemistry, Department of Biochemistry/Molecular Biology, Kobe University Graduate School of Medicine, Kobe, 650-0017, Japan.
Cell Signal. 2009 Jan;21(1):7-13. doi: 10.1016/j.cellsig.2008.07.011. Epub 2008 Jul 22.
Sphingolipids were once regarded as inert structural components of cell membranes. Now these metabolites are generally believed to be important bioactive molecules that control a wide repertoire of cellular processes such as proliferation and survival of cells. Along with these ubiquitous cell functions observed in many peripheral tissues sphingolipid metabolites, especially sphingosine 1-phosphate, exert important neuron-specific functions such as regulation of neurotransmitter release. This review summarizes physiological and pathological roles of sphingolipid metabolites emphasizing the role of sphingosine 1-phosphate in the central nervous system.
鞘脂曾被视为细胞膜的惰性结构成分。现在普遍认为这些代谢产物是重要的生物活性分子，可控制多种细胞过程，如细胞增殖和存活。除了在许多外周组织中观察到的这些普遍存在的细胞功能外，鞘脂代谢产物，尤其是1-磷酸鞘氨醇，还发挥着重要的神经元特异性功能，如调节神经递质释放。本综述总结了鞘脂代谢产物的生理和病理作用，重点强调了1-磷酸鞘氨醇在中枢神经系统中的作用。
