Siddiqui Ibadur R, Srivastava Vishal, Singh Pravin K
Department of Chemistry, Laboratory of Green Technology-Synthesis Division, University of Allahabad, Allahabad, India.
Nucleosides Nucleotides Nucleic Acids. 2008 Aug;27(8):992-1000. doi: 10.1080/15257770802258042.
One-pot montmorillonite K-10 clay-supported reactions of substituted/unsubstituted salicylaldehyde and ribosyl/deoxyribosyl thioureas expeditiously yielded novel N-nucleosides, 4-hydroxy-3,4-dihydro-3-(beta-D-ribofuranosyl or beta-D-2'-deoxyribofuranosyl)-2''-benz[e]-1,3-oxazin-2-thione via cycloisomerization of aldehyde intermediate under solvent-free microwave irradiation conditions.
在无溶剂微波辐射条件下，通过醛中间体的环异构化反应，一锅法使取代/未取代的水杨醛与核糖基/脱氧核糖基硫脲在蒙脱石K-10黏土负载下快速生成新型N-核苷，即4-羟基-3,4-二氢-3-（β-D-呋喃核糖基或β-D-2'-脱氧呋喃核糖基）-2''-苯并[e]-1,3-恶嗪-2-硫酮。
