矿物质负载下新型4-羟基苯并恶嗪-2-硫酮N-核苷的简便合成

Mineral supported facile synthesis of novel 4-hydroxybenzoxazin-2-thione N-nucleosides.

作者信息

Siddiqui Ibadur R, Srivastava Vishal, Singh Pravin K

机构信息

Department of Chemistry, Laboratory of Green Technology-Synthesis Division, University of Allahabad, Allahabad, India.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2008 Aug;27(8):992-1000. doi: 10.1080/15257770802258042.

DOI:10.1080/15257770802258042

PMID:18696367

Abstract

One-pot montmorillonite K-10 clay-supported reactions of substituted/unsubstituted salicylaldehyde and ribosyl/deoxyribosyl thioureas expeditiously yielded novel N-nucleosides, 4-hydroxy-3,4-dihydro-3-(beta-D-ribofuranosyl or beta-D-2'-deoxyribofuranosyl)-2''-benz[e]-1,3-oxazin-2-thione via cycloisomerization of aldehyde intermediate under solvent-free microwave irradiation conditions.

摘要

在无溶剂微波辐射条件下，通过醛中间体的环异构化反应，一锅法使取代/未取代的水杨醛与核糖基/脱氧核糖基硫脲在蒙脱石K-10黏土负载下快速生成新型N-核苷，即4-羟基-3,4-二氢-3-（β-D-呋喃核糖基或β-D-2'-脱氧呋喃核糖基）-2''-苯并[e]-1,3-恶嗪-2-硫酮。

相似文献

Mineral supported facile synthesis of novel 4-hydroxybenzoxazin-2-thione N-nucleosides.矿物质负载下新型4-羟基苯并恶嗪-2-硫酮N-核苷的简便合成

Nucleosides Nucleotides Nucleic Acids. 2008 Aug;27(8):992-1000. doi: 10.1080/15257770802258042.

Novel salicylaldehyde-based mineral-supported expeditious synthesis of benzoxazin-2-ones.基于新型水杨醛的矿物负载快速合成苯并恶嗪-2-酮

J Org Chem. 2004 Nov 12;69(23):8118-20. doi: 10.1021/jo0492315.

CeCl₃.7H2O/NaI-promoted direct synthesis of 1,3-benzoxazine-2-thione n-nucleosides under microwave irradiation.CeCl₃·7H₂O/NaI促进下微波辐射直接合成1,3-苯并恶嗪-2-硫酮N-核苷

Nucleosides Nucleotides Nucleic Acids. 2013;32(5):247-55. doi: 10.1080/15257770.2013.783702.

Domino reaction involving (diacetoxyiodo)benzene- promoted oxidative rearrangement: a novel multicomponent and efficient strategy for the synthesis of thiadiazole N-nucleosides.涉及（二乙酰氧基碘）苯促进的氧化重排的多米诺反应：一种合成噻二唑N-核苷的新型多组分高效策略。

Nucleosides Nucleotides Nucleic Acids. 2013;32(8):453-63. doi: 10.1080/15257770.2013.809456.

An expeditious synthesis of benzoxazine-2-thione c-nucleosides Via Cu(OTf)2-mediated dehydrazinative beta-glycosylation.

Nucleosides Nucleotides Nucleic Acids. 2008 Dec;27(12):1227-37. doi: 10.1080/15257770802458212.

Microwave-assisted synthesis of acyclic C-nucleosides from 1,2- and 1,3-diketones.

Nucleosides Nucleotides Nucleic Acids. 2009 Mar;28(3):175-83. doi: 10.1080/15257770902830997.

Montmorillonite K-10 clay-catalyzed Ferrier rearrangement of 2-C-hydroxymethyl-d-glycals, 3,4,6-tri-O-alkyl-d-glycals, and 3,4-(dihydro-2H-pyran-5-yl)methanol: a few unexpected domino transformations.蒙脱石 K-10 粘土催化的 2-C-羟甲基-d-葡萄糖苷、3,4,6-三-O-烷基-d-葡萄糖苷和 3,4-(二氢-2H-吡喃-5-基)甲醇的 Ferrier 重排：一些意想不到的多米诺转化。

Carbohydr Res. 2011 Sep 27;346(13):1654-61. doi: 10.1016/j.carres.2011.03.027. Epub 2011 Mar 21.

Cysteine, thiourea and thiocyanate interactions with clays: FT-IR, Mössbauer and EPR spectroscopy and X-ray diffractometry studies.半胱氨酸、硫脲和硫氰酸盐与粘土的相互作用：傅里叶变换红外光谱、穆斯堡尔和电子顺磁共振波谱及 X 射线衍射研究。

Amino Acids. 2010 Apr;38(4):1089-99. doi: 10.1007/s00726-009-0318-8. Epub 2009 Jul 5.

Synthesis by microwave irradiation of a substituted benzoxazine parallel library with preferential relaxant activity for guinea pig trachealis.通过微波辐射合成具有对豚鼠气管优先松弛活性的取代苯并恶嗪平行文库。

Eur J Med Chem. 2004 Oct;39(10):815-26. doi: 10.1016/j.ejmech.2004.05.003.

A nucleotide dimer synthesis without protecting groups using montmorillonite as catalyst.以蒙脱石为催化剂，无需保护基团的核苷酸二聚体合成。

Nucleosides Nucleotides Nucleic Acids. 2012;31(7):536-66. doi: 10.1080/15257770.2012.701787.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。