Bronner Irene M, Hoogendijk Jessica E, Veldman Henk, Ramkema Marja, van den Bergh Weerman Marius A, Rozemuller Annemieke J M, de Visser Marianne
Department of Neurology, Flevoziekenhuis, Almere, The Netherlands.
Ultrastruct Pathol. 2008 Jul-Aug;32(4):123-6. doi: 10.1080/01913120802209379.
In dermatomyositis (DM) there is strong histopathological evidence of a microvascular pathogenesis, including endothelial microtubular inclusions. In nonspecific myositis, perimysial and perivascular infiltrates in the muscle biopsy similar to DM are found. Microtubular inclusions in endothelial cells were systematically searched for and found in 4 of the 20 muscle biopsies of nonspecific myositis patients (20%). Three had a CTD (SLE, scleroderma, and Sjogren syndrome). Ten patients with DM and 5 patients with sporadic inclusion body myositis served as positive and negative controls, respectively.
在皮肌炎（DM）中，有强有力的组织病理学证据支持微血管发病机制，包括内皮微管包涵体。在非特异性肌炎中，肌肉活检发现肌束膜和血管周围浸润，类似于皮肌炎。对内皮细胞中的微管包涵体进行系统查找，在20例非特异性肌炎患者的肌肉活检中有4例（20%）发现了这种包涵体。其中3例患有结缔组织病（系统性红斑狼疮、硬皮病和干燥综合征）。分别以10例皮肌炎患者和5例散发性包涵体肌炎患者作为阳性和阴性对照。
