Lahti Tuuli A, Partonen Timo, Kyyrönen Pentti, Kauppinen Timo, Pukkala Eero
Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, Helsinki, Finland.
Int J Cancer. 2008 Nov 1;123(9):2148-51. doi: 10.1002/ijc.23566.
Our aim was to find out whether non-Hodgkin lymphoma (NHL) was more common than expected among night-time shift workers. The Finnish job-exposure matrix (FINJEM) provided estimates of the proportion of exposed persons and the mean level of exposure among the exposed in each occupation. The probability of night-time work in each occupation was assessed, the observed and expected numbers of cancer cases in a cohort of persons born in 1906-1945 during the years of 1971-1995 were calculated, and the cumulative index of night-time work was scored. The cohort compromised of 1,669,272 persons of whom 6,307 (3,813 men and 2,494 women) had NHL during the follow-up. Night-time work increased significantly (p = 0.01) the risk of NHL in men, the overall relative risk being 1.10 (95% confidence interval of 1.03-1.19). Using the lag period of 10 years, the risk ratio was 1.28 (1.03-1.59) for men who worked in night-time shifts to a high degree as compared with those who had not been exposed to night-time work. Night-time workers are cancer prone and have a greater risk of NHL than population on average.
我们的目的是查明非霍奇金淋巴瘤（NHL）在夜间轮班工人中是否比预期更为常见。芬兰工作暴露矩阵（FINJEM）提供了各职业中暴露人群的比例估计值以及暴露人群中的平均暴露水平。评估了各职业中夜间工作的概率，计算了1906年至1945年出生的人群在1971年至1995年期间观察到的和预期的癌症病例数，并对夜间工作的累积指数进行了评分。该队列由1,669,272人组成，其中6,307人（3,813名男性和2,494名女性）在随访期间患非霍奇金淋巴瘤。夜间工作显著增加了男性患非霍奇金淋巴瘤的风险（p = 0.01），总体相对风险为1.10（95%置信区间为1.03 - 1.19）。采用10年的潜伏期，与未接触夜间工作的男性相比，高度从事夜间轮班工作的男性风险比为1.28（1.03 - 1.59）。夜间工作者易患癌症，患非霍奇金淋巴瘤的风险高于一般人群。
