Thongtang Nuntakon, Sriwijitkamol Apiradee
Division of Endocrinology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 2008 Jun;91(6):943-54.
Type 2 diabetes mellitus is a worldwide health problem. Adequate glycemic control can help to prevent many chronic diabetic complications. Despite the availability of several classes of oral hypoglycemic agents and insulin, many patients fail to achieve adequate glycemic control. Incretins are gut hormones produced in response to ingestion of nutrients. Glucagon-like peptide-1 (GLP-1), one of the incretin hormones, has pleiotropic actions on the control of blood glucose. Clinical trials with the incretin mimetic and Dipeptidyl peptidase-IV inhibitors demonstrate promising results in the improvement of glucose homeostasis.
2型糖尿病是一个全球性的健康问题。充分的血糖控制有助于预防许多慢性糖尿病并发症。尽管有几类口服降糖药和胰岛素可供使用，但许多患者仍未能实现充分的血糖控制。肠促胰岛素是在摄入营养物质后产生的肠道激素。胰高血糖素样肽-1（GLP-1）是一种肠促胰岛素激素，对血糖控制具有多效性作用。使用肠促胰岛素类似物和二肽基肽酶-4抑制剂的临床试验在改善葡萄糖稳态方面显示出了有前景的结果。
